Previously, we showed that transient inhibition of TGF- β1 resulted in correction of key aspects of diabetes-induced CD34(+) cell dysfunction. In this report, we examine the effect of transient inhibition of plasminogen activator inhibitor-1 (PAI-1), a major gene target of TGF-β1 activation. Using gene array studies, we examined CD34(+) cells isolated from a cohort of longstanding diabetic indi...

The concept of the IT Project Management Office (PMO) appears to be rapidly growing in popularity and influence globally. This indicates considerable interest in the industry on the potential of the IT PMO, a central element of IT project management in organisations. Although established to ensure project success, the value of these IT PMOs is being questioned, putting them in a paradoxical sit...

Suatu perusahaan penyedia solusi teknologi informasi, PQR, menjalankan bisnisnya berbasiskan proyek yang dikelola departemen Program Management Office (PMO). Implementasi penyelesaian proyek-proyek PQR belum memenuhi target ketepatan waktu 95%, PMO mencatat 12 dari 14 pada 2019-2021 terlambat selesai. Untuk meminimalisir potensi kerugian bisnis, perusahaaan perlu memperbaiki penerapan manajemen...

A substantial body of evidence indicates that aged-related changes in the fluidity and lipid composition of the plasma membrane contribute to cellular dysfunction in humans and other mammalian species. In the CNS, reductions in neuronal plasma membrane order (PMO) (i.e., increased plasma membrane fluidity) have been attributed to age as well as the presence of the beta-amyloid peptide-25-35, kn...

One-dimensional periodic mesoporous organosilica (PMO) nanoparticles with tunable aspect ratios are obtained from a chain-type molecular precursor octaethoxy-1,3,5-trisilapentane. The aspect ratio can be tuned from 2:1 to >20:1 simply by variation in the precursor concentration in acidic aqueous solutions containing constant amounts of triblock copolymer Pluronic P123. The mesochannels are high...

Healthcare management and public health have been significantly grown over decades. Based on report presented by Center for Medicare and Medicaid Services (CMS), healthcare spending will grow to about 19.8% of US GDP by 2020. Other countries have spent huge investment on health sector as well. Therefore, in order to improve public health services and with the aim of attaining better performance...

In the asymmetric unit of the title salt, (C(5)H(12)NO)(6)[PMo(12)O(40)](2)·5C(5)H(11)NO, there are two independent α-Keggin-type [PMo(12)O(40)](3-) polyoxidoanions, which show characteristic features with respect to bond lengths and angles. One of the [CH(3)CH(2)C(=OH)N(CH(3))(2)](+) cations is hydrogen bonded to the neighboring polyoxidoanion through a C=O-H⋯O(bridge) hydrogen bond. The organ...

a new hybrid nanomaterial was developed by immobilization of phosphomolybdate anions on the surface of modified magnetite nanoparticles with quaternary phosphonium cations. silica coated magnetic nanoparticles supported phosphonium cations, ph3p+-scmnps, were prepared by covalent attachment of chloropropylsilyl groups on the surface of silica coated magnetite nanoparticles and next reaction wit...