نتایج جستجو برای: pmn

تعداد نتایج: 3528  

Journal: :Neonatology 2010
Caroline N Nguyen Patricia M Schnulle Nasser Chegini Xiaoping Luo Joyce M Koenig

BACKGROUND The resolution of inflammation involves the efficient removal of apoptotic neutrophils (PMN). However, a subpopulation of PMN that are resistant to apoptosis may contribute to PMN persistence in tissues, an early hallmark of chronic inflammation. We previously made observations that neonatal PMN with prolonged survival had augmented expression of CD18/CD11b, an adhesion molecule crit...

Journal: :Journal of Leukocyte Biology 2009
Hsin-Ni Li Peter G. Barlow Johan Bylund Annie Mackellar Åse Björstad James Conlon Pieter S. Hiemstra Chris Haslett Mohini Gray A. John Simpson Adriano G. Rossi Donald J. Davidson

Cathelicidins are CHDP with essential roles in innate host defense but also more recently associated with the pathogenesis of certain chronic diseases. These peptides have microbicidal potential and the capacity to modulate innate immunity and inflammatory processes. PMN are key innate immune effector cells with pivotal roles in defense against infection. The appropriate regulation of PMN funct...

Journal: :Hypertension research : official journal of the Japanese Society of Hypertension 2003
Kensaku Maeda Kenichi Yasunari Eisuke F Sato Junichi Yoshikawa Masayasu Inoue

The involvement of oxidative stress in polymorphonuclear leukocytes (PMN) in the pathogenesis of hypertension remains to be elucidated. We analyzed the generation of reactive oxygen species (ROS) by the circulating and peritoneally infiltrating PMN from spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). Flow cytometric analysis revealed that ROS generation by PMN from SHR was hi...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2006
Camila Sardenberg Paulo Suassuna Maria Claudia Cruz Andreoli Renato Watanabe Maria Aparecida Dalboni Sílvia Regina Manfredi Oscar Pavão dos Santos Esper Georges Kallas Sérgio Antônio Draibe Miguel Cendoroglo

BACKGROUND Previous studies have reported that incubation of polymorphonuclear cells (PMN) in uraemic plasma or with different haemodialysis membranes and peritoneal dialysis solutions increases apoptosis in this cell type. In addition, PMN harvested from uraemic patients show a reduced ability to generate superoxide in response to stimuli as well as impaired phagocytosis, chemotaxis and degran...

Journal: :Journal of immunology 2000
A J Meszaros J S Reichner J E Albina

Macrophages (Mphi) contribute to the resolution of early inflammation by recognizing and ingesting apoptotic polymorphonuclear neutrophils (PMN). In addition, experiments reported here demonstrated that Mphi can actively induce PMN apoptosis. Coculture of cells from 2- or 5-day-old wounds in rats, or of Mphi purified from such preparations, with PMN-rich wound cell populations obtained 1 day af...

Journal: :Journal of dairy science 2002
K Van Oostveldt M J Paape C Burvenich

In a two-chamber system, isolated blood polymorphonuclear neutrophil leukocytes (PMN) were allowed to migrate (5 h, 37degrees C) in response to bovine complement component C5a across calfskin and rat-tail type I collagen-coated micropore membranes, arterial endothelial, or mammary epithelial cell monolayer on calfskin and rat-tail collagen-coated membranes, respectively. Migration through calfs...

Journal: :Journal of leukocyte biology 1997
K A Aziz J C Cawley A T Treweeke M Zuzel

In a recent study, we showed that granulocyte-macrophage colony-stimulating factor (GM-CSF) and supernatants from partially stimulated platelets undergoing selective alpha-granule release synergistically enhanced polymorphonuclear leukocyte (PMN) response to N-formyl-methionyl-leucyl-phenylalanine (fMLP). The active factor released from platelet alpha-granules was identified as platelet factor ...

Journal: :Molecular human reproduction 2000
F Saez C Motta D Boucher G Grizard

Prostasomes are particular lipid vesicles secreted by the prostate in human semen and involved in several physiological functions such as the improvement of sperm motility or immunomodulation. We have previously shown that they reduced the overall reactive oxygen species (ROS) production of seminal polymorphonuclear neutrophils (PMN). The present study was conducted to define the mechanism by w...

Journal: :Veterinary research 2000
Z Sládek D Rysánek

The dynamics of apoptosis of polymorphonuclear leukocytes (PMN) during induced influx of PMN into the cavity system of the juvenile bovine mammary gland in order to investigate the role of apoptosis of PMN in the resolution of mastitis was studied. The instillation of a synthetic analogue of muramyl dipeptide into teat sinus of the sixteen mammary glands was followed by a massive influx of PMN ...

Journal: :Vaccine 2004
Tetsuo Kobayashi Ayano Takauchi Annemiek B van Spriel Henriette A Vilé Mitsuo Hayakawa Yasuko Shibata Yoshimitsu Abiko Jan G J van de Winkel Hiromasa Yoshie

Phagocytosis and killing of pathogens by polymorphonuclear neutrophils (PMN) from gingival crevicular fluid (GCF) is diminished in chronic periodontitis patients. As an approach to improve targeting of PMN toward a periodontopathogen, Porphyromonas gingivalis, the efficacy of a bispecific antibody (BsAb) directed against both recombinant 130 kDa hemagglutinin domain (r130k-HMGD) of P. gingivali...

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