Target based chemical screens are a mainstay of modern drug discovery, but the effectiveness of this reductionist approach is being questioned in light of declines in pharmaceutical R & D efficiency. In recent years, phenotypic screens have gained increasing acceptance as a complementary/alternative approach to early drug discovery. We discuss the various model organisms used in phenotypic scre...

Friction stir welding has become a popular forging technique used in many applications. The Swedish Nuclear Fuel and Waste Management Company (SKB) evaluates this method to seal the 5 cm thick copper canisters that will contain the spent nuclear fuel. To produce repetitive, high quality welds, the process must be controlled, and today a cascade controller is used to keep the desired stir zone t...

Numerical and experimental methods are described for the investigation of an oscillating-wing generator or wingmill. The numerical approach applies a previously developed, unsteady, in-compressible panel method incorporating a non-linear, deforming wake model to compute the unsteady ow about an airfoil undergoing speciied pitch and plunge motions. An experimental model is described which can du...

Abstract The peak loads experienced by aircraft of all scales will typically be during gusts, turbulence or extreme manoeuvres. Understanding the aerodynamic response to these transient disturbances is therefore crucial, particularly when Leading-Edge Vortices (LEVs) occur. This fundamental study investigates a wide range plunging motions. exhibited strong dependence motion amplitude yet remain...

Plunge depth is one of the most important process parameters that affect joint strength in refill friction stir spot welding (refill FSSW). In this study, a three-dimensional numerical model developed using Lagrangian incremental formulation DEFORM-3D to simulate FSSW thin AA7075-T6 sheets. The verified by comparing obtained temperatures at specific locations with from previous experimental stu...