Song, Jianliang, Xue-Qian Zhang, Lois L. Carl, Anwer Qureshi, Lawrence I. Rothblum, and Joseph Y. Cheung. Overexpression of phospholemman alters contractility and [Ca2 ]i transients in adult rat myocytes. Am J Physiol Heart Circ Physiol 283: H576–H583, 2002. First published May 2, 2002; 10.1152/ajpheart.00197.2002.—Previous studies showed increased phospholemman (PLM) mRNA after myocardial infa...

This publication discusses the evolution of CAD, CAM, and CAE tools through product data management systems into today’s product lifecycle management (PLM), followed by a review of the characteristics and benefits of PLM. Current practices and potential applications of PLM in aviation maintenance, repair and overhaul (MRO) are discussed through case studies, two of which were from the authors’ ...

The technique for efficiently managing management resources by ERP (Enterprise Resource Planning) and SCM (Supply-Chain Management) has been widely introduced in the manufacturing business before. Recently, PLM (Product Lifecycle Management) to which ERP and SCM is enhanced is spreading. PLM is paid to attention now by the technique for managing the product planning, the design, manufacturing, ...

Because phospholemman (PLM) regulates the Na(+)/K(+) pump (NKA) and is a major cardiac phosphorylation target for both protein kinase A (at Ser68) and protein kinase C (PKC) (at both Ser63 and Ser68), we evaluated whether PLM mediates the PKC-dependent regulation of NKA function and protein kinase A/PKC crosstalk in ventricular myocytes. PKC was activated by PDBu (300 nmol/L), and we measured N...

Secreted proteins of the Wnt family affect axon guidance, asymmetric cell division, and cell fate. We show here that C. elegans Wnts acting through Frizzled receptors can shape axon and dendrite trajectories by reversing the anterior-posterior polarity of neurons. In lin-44/Wnt and lin-17/Frizzled mutants, the polarity of the PLM mechanosensory neuron is reversed along the body axis: the long P...

Since 1958 pagano-Levin medium (PLM) has been used as an aid in the identification of Candida albicans. However, no statistical analysis of its effectiveness based on large number of random human specimens has been reported. The present study compared PLM (now called Candida test) with Sabouraud's plus antimicrobials and Littman's ox-gall agar without antimicrobials. Of 500 random vaginal sampl...

Product Lifecycle Management (PLM) innovates as it defines both the product as a central element to aggregate enterprise information and the lifecycle as a new time dimension for information integration and analysis. Because of its potential benefits to shorten innovation lead-times and to reduce costs, PLM has attracted a lot of attention at industry and at research. However, the current PLM i...

Human phospholemman (PLM) is a 72-residue protein, which is expressed at high density in the cardiac plasma membrane and in various other tissues. It forms ion channels selective for K+, Cl-, and taurine in lipid bilayers and colocalizes with the Na+/K+-ATPase and the Na+/Ca2+-exchanger, which may suggest a role in the regulation of cell volume. Here we present the first structural data based o...

Product lifecycle management (PLM) defines how to manage and automate product lifecycle processes, from product conceptualization to retirement. This paper outlines both the fundamental concepts and the key functional components of a PLM system. It describes key industry imperatives such as virtual product development, product-process-resources methodology, a collaborative PLM, and correspondin...

In the modern global economy, companies are facing ever-increasing challenges for short time-to-market to enter into the market early, for reduced time-to-volume to occupy the market quickly, and for decreased time-to-profit to get return from market shortly. Product lifecycle management (PLM) is recognized as one of the key leading technologies to facilitate companies to overcome these challen...