Ninety-five renal transplant recipients from an endemic area of tuberculosis were investigated to find out the prevalence and course of tuberculosis in pre- and post-transplant periods. Eleven patients had tuberculosis in the pre-transplant period - pulmonary (2), pleural (2), miliary (1), abdominal (2), lymph node (5) and pericardial (1). They were transplanted after antituberculous therapy of...

To investigate the role of interleukin (IL)-18 in human tuberculosis, IL-18 production was evaluated in blood and at the site of disease in patients with tuberculosis. Mycobacterium tuberculosis-stimulated peripheral blood mononuclear cells (PBMC) from tuberculosis patients secreted less IL-18 and interferon-gamma (IFN-gamma) than did PBMC from healthy persons reactive to tuberculin. M. tubercu...

OBJECTIVE To improve physicians' ability to discriminate tuberculous from malignant pleural effusions through a simple clinical algorithm that avoids pleural biopsy. DESIGN We retrospectively compared the clinical and pleural fluid features of 238 adults with pleural effusion who satisfied diagnostic criteria for tuberculosis (n=64) or malignancy (n=174) at one academic center (derivation coh...

background :   tuberculosis  is one of the most important causes of morbidity and mortality worldwide. approximately 10-20% of tuberculosis is extra- pulmonary tuberculosis (eptb), which is much higher (50%) in patients suffering from immunity defects such as aids. eptb diagnosis is difficult mostly because of various clinical manifestations  and aggressive  procedures needed for its diagnosis....

A 46-year-old woman developed a right pleural effusion 8 weeks after standard chemotherapy for tuberculous pleurisy on the left side had been started. Pleural biospy demonstrated caseous granulomatous changes. The patient improved following continuation of the same treatment.

BACKGROUND Early pleural tuberculosis (TB) diagnosis is particularly difficult. The aim of this study was to investigate the diagnostic accuracy of the Xpert MTB/RIF (Xpert) (Cepheid, Sunnyvale, CA) assay using pleural biopsy and pleural fluid specimens in patients with suspected pleural TB but who had a negative sputum acid-fast bacilli (AFB) smear. MATERIALS AND METHODS In this study, 134 s...

OBJECTIVE To investigate the incidence, clinical features, and treatment of tuberculous pleurisy in AIDS patients. METHODS We reviewed all cases of pleural tuberculosis in AIDS patients in South Carolina from 1988 through 1994. Clinical findings, test results, treatment, and outcome were analyzed. MAIN RESULTS Twenty-two (11%) of the 202 AIDS patients with tuberculosis had pleural involveme...

Background: Empyema thoracis may occur from parapneumonic pleural effusion and is associated with prolonged respiratory symptoms requiring longer times for drainage. Suppurative bacterial infections and tuberculosis are important causes; which if not treated early, may result to chronic empyema requiring thoracotomy and decortication. Objectives: To highlight the diagnostic and treatment challe...

Tuberculous pyopneumothorax is a rare but serious complication of evolutive pulmonary tuberculosis. We report a series of 18 cases with tuberculous pyopneumothorax admitted to the Pneumo-Phthisiology Department of the Mohammed V Military Teaching Hospital in Rabat between January 2005 and December 2009. Our study included 15 men and 3 women, the average age was 35 ± 7 years. 4 patients were dia...

A prospective study of 111 adult patients with a pleural effusion was carried out in an area with a high prevalence of tuberculosis to compare the yield of bedside with laboratory inoculation of pleural fluid, and the yield and speed of a radiometric mycobacterial culture system (BACTEC) with that of conventional culture. The use of adenosine deaminase activity in pleural fluid as a diagnostic ...