the development of metal-based therapeutics. Cisplatin is one platinum complex and is widely used in treatments for cancer. Shimizu and Tsuji established a method of preparing colloidal platinum particles, whose average size is 2 nm, by ethanol reduction of H2PtCl6 in the absence of protective agents such as hydrophilic polymers. They used only the chemicals permitted to food additives such as ...

BACKGROUND Ovarian cancer remains an on-going challenge mainly due to the development of drug resistance and also because the cancer is likely to have metastasized at the time of diagnosis. Currently, chemotherapy based on platinum drugs such as cisplatin is the primary treatment for the disease. Copper transporter 1 is involved in the transport of cisplatin into the cell, but is also down-regu...

Platinum resistance is a critical barrier for clinicians to improve the survival of ovarian cancer. Our study evaluated the correlation between copy number variations (CNVs) of neurotrophic tyrosine receptor kinase 3 (NTRK3) and the prognosis of ovarian cancer, which might predict platinum resistance in ovarian cancer patients.Array comparative genomic hybridization (CGH) was used to test gene ...

Platinum is ubiquitous in the production sectors of chemicals and fuels; however, its scarcity in nature and high price will limit future proliferation of platinum-catalysed reactions. One promising approach to conserve platinum involves understanding the smallest number of platinum atoms needed to catalyse a reaction, then designing catalysts with the minimal platinum ensembles. Here we design...

Acquisition of platinum resistance following first line platinum/taxane therapy is commonly observed in ovarian cancer patients and prevents clinical effectiveness. There are few options to prevent platinum resistance; however, demethylating agents have been shown to resensitize patients to platinum therapy thereby demonstrating that DNA methylation is a critical contributor to the development ...

In this research, the electrocatalytic activity of platinum-ruthenium nanoparticles on carbon nanotubes and black in methanol oxidation reaction has been investigated. Moreover, electrochemical performance a single passive direct fuel cell run by these two different electrocatalysts reported. Physical characterization tests reveal superiority PtRu nanotubes. Based voltammetry outcomes, it was f...

Background and Aim: Preparation of root canal with rotary nickel-titanium (NiTi) instruments may potentially create microcracks that can lead to vertical root fracture. This study aimed to compare the incidence of crack formation by BioRaCe and Edge Taper Platinum systems in the mesiobuccal canals of extracted first mandibular molars. Materials and Methods: In this experimental study, 50 first...

The cathodic dissolution of platinum, resulting from the oxygen reduction reaction (ORR) or hydrogen peroxide reduction on platinum, has been investigated. Highly oxidizing hydroxyl radicals (OH•) are believed to be the species responsible for the platinum dissolution phenomenon. These radicals are produced from the ORR byproduct, hydrogen peroxide, through a 1 electron reduction pathway (H2O2 ...

Although ovarian carcinomas with mutated BRCA1 or BRCA2 are sensitive to platinum compounds, such carcinomas eventually develop platinum resistance. Previously, we showed that acquired resistance to cisplatin in BRCA2-mutated tumors can be mediated by secondary intragenic mutations in BRCA2 that restore the wild-type BRCA2 reading frame. Here, we show that secondary mutations of BRCA1 also occu...

Platinum-based catalysts have been considered the most effective electrocatalysts for the hydrogen evolution reaction in water splitting. However, platinum utilization in these electrocatalysts is extremely low, as the active sites are only located on the surface of the catalyst particles. Downsizing catalyst nanoparticles to single atoms is highly desirable to maximize their efficiency by util...