نتایج جستجو برای: plasticity reelin

تعداد نتایج: 58657  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Lluís Pujadas Agnès Gruart Carles Bosch Lídia Delgado Cátia M Teixeira Daniela Rossi Luis de Lecea Albert Martínez José M Delgado-García Eduardo Soriano

Reelin, an extracellular protein essential for neural migration and lamination, is also expressed in the adult brain. To unravel the function of this protein in the adult forebrain, we generated transgenic mice that overexpress Reelin under the control of the CaMKIIalpha promoter. Overexpression of Reelin increased adult neurogenesis and impaired the migration and positioning of adult-generated...

2016
Liang Lin Fan Yan Dandan Zhao Meng Lv Xiaodong Liang Hui Dai Xiaodan Qin Yan Zhang Jie Hao Xiuyuan Sun Yanhui Yin Xiaojun Huang Jun Zhang Jin Lu Qing Ge

Reelin is an extracellular matrix (ECM) protein that is essential for neuron migration and positioning. The expression of reelin in multiple myeloma (MM) cells and its association with cell adhesion and survival were investigated. Overexpression, siRNA knockdown, and the addition of recombinant protein of reelin were used to examine the function of reelin in MM cells. Clinically, high expressio...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
J W Yip Y P Yip K Nakajima C Capriotti

Mutation of the reeler gene (Reln) disrupts neuronal migration in several brain regions and gives rise to functional deficits such as ataxic gait and trembling in the reeler mutant mouse. Thus, the Reln product, reelin, is thought to control cell-cell interactions critical for cell positioning in the brain. Although an abundance of reelin transcript is found in the embryonic spinal cord [Ikeda,...

Journal: :Neuron 1999
Gabriella D'Arcangelo Ramin Homayouni Lakhu Keshvara Dennis S Rice Michael Sheldon Tom Curran

A signaling pathway involving the extracellular protein Reelin and the intracellular adaptor protein Disabled-1 (Dab1) controls cell positioning during mammalian brain development. Here, we demonstrate that Reelin binds directly to lipoprotein receptors, preferably the very low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2). Binding requires calcium, and it is inh...

Journal: :Brain : a journal of neurology 2001
S H Eriksson M Thom J Heffernan W R Lin B N Harding M V Squier S M Sisodiya

Cajal-Retzius (CR) cells are early-developing cells important in mammalian corticogenesis. Reelin, a protein secreted by CR cells, is essential for completion of neuronal migration and cortical lamination. Lack of reelin causes the 'reeler' phenotype in mice and autosomal recessive lissencephaly with cerebellar hypoplasia in man. Focal increases in reelin and CR cells are associated with thicke...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2005
Mélanie Sinagra Danièle Verrier Daniela Frankova Kimberly M Korwek Jaroslav Blahos Edwin J Weeber Olivier J Manzoni Pascale Chavis

Reelin is a secreted protein that regulates brain layer formation during embryonic development. Reelin binds several receptors, including two members of the low-density lipoprotein (LDL) receptor family, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR). Despite the high level of expression of Reelin and ApoER2 in the postnatal brain, their functions...

2017
Liang Lin Xinwei Zhang Li Cao Quanming An Jie Hao Yan Zhang Rong Jin Yingjun Chang Xiaojun Huang Jin Lu Qing Ge

The close interaction between tumor cells and bone marrow stromal cells plays a crucial role in the tumorigenesis of multiple myeloma (MM). Reelin, an extracellular matrix protein, is found expressed in myeloma cells and is negatively associated with prognosis. We examined the role of Reelin in myeloma cell adhesion to bone marrow stromal cells and the signaling pathways involved. The results r...

Journal: :Neuron 2012
Katsutoshi Sekine Takeshi Kawauchi Ken-ichiro Kubo Takao Honda Joachim Herz Mitsuharu Hattori Tatsuo Kinashi Kazunori Nakajima

Birthdate-dependent neuronal layering is fundamental to neocortical functions. The extracellular protein Reelin is essential for the establishment of the eventual neuronal alignments. Although this Reelin-dependent neuronal layering is mainly established by the final neuronal migration step called "terminal translocation" beneath the marginal zone (MZ), the molecular mechanism underlying the co...

Journal: :Neuron 1999
Thomas Hiesberger Marion Trommsdorff Brian W Howell Andre Goffinet Marc C Mumby Jonathan A Cooper Joachim Herz

The large extracellular matrix protein Reelin is produced by Cajal-Retzius neurons in specific regions of the developing brain, where it controls neuronal migration and positioning. Genetic evidence suggests that interpretation of the Reelin signal by migrating neurons involves two neuronal cell surface proteins, the very low density lipoprotein receptor (VLDLR) and the apoE receptor 2 (ApoER2)...

2012
Sabine Hellwig Iris Hack Birgit Zucker Bianka Brunne Dirk Junghans

One pathway regulating the migration of neurons during development of the mammalian cortex involves the extracellular matrix protein Reelin. Reelin and components of its signaling cascade, the lipoprotein receptors ApoER2 and Vldlr and the intracellular adapter protein Dab1 are pivotal for a correct layer formation during corticogenesis. The olfactory bulb (OB) as a phylogenetically old cortica...

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