POEMS syndrome is an acronym for polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes, which is a rare paraneoplastic disease of monoclonal plasma cells. A mandatory criterion to diagnose POEMS syndrome is the presence of a monoclonal plasma cell dyscrasia in which plasma cell leukemia is the most aggressive form. Early identification of the features of the POEMS...

Plasma cell leukemia (PCL) is a rare and aggressive manifestation of malignant plasma cell proliferation and corresponds to 2–4% of multiple myeloma (MM) cases.1,2 The World Health Organization (WHO) defines PCL by the presence of high levels (at least 2 × 109/L) of clonal plasma cells in the peripheral blood (PB) or at least 20% of the leukocyte differential count.1 Primary PCL (pPCL) correspo...

introduction : heat shock proteins (hsps) are molecular chaperones involved in protein folding, stability and turnover, and due to their role in cancer progression, the effect of low power laser irradiation (lpli) on the expression of hsp70 and hsp90 in jurkat e6.1 t-lymphocyte leukemia (jelt) cell line was investigated in vitro. methods : jetl cells were irradiated with lpli at 635nm and 780m ...

T-cell acute lymphoblastic leukemia is an aggressive hematologic malignancy which is usuallyassociated with unfavorable prognosis particularly in patients with refractory/relapsed disease.Therefore, development of novel therapeutic strategies is highly required for improving theoutcome of these patients. Although there are several studies evaluating the efficacy of proteasome<...

conclusions it was demonstrated that the presence of del6q21 in b-cll patients indicates poor prognosis and on the contrary, presence of del17p13 points at the good prognostic value of the disease. results deletion of 17p13 was found in 11 (16.6%) and deletion 6q21 was present in 5 (7.5%). statistical analyses were performed to investigate the correlation of these molecular-cytogenetic findings...

H ere, we describe a 52-year-old woman with a history of primary plasma cell leukemia (PCL) who achieved complete remission after the tandem of autologous and nonmyeloablative allogeneic stem cell transplantation (SCT). Nine months after the allogeneic SCT, she presented with oculomotor and trochlear nerve palsy (diplopia, ptosis of the right upper eye lid, and dilated right pupil). Physical ex...

A 55-year-old man was admitted with fever and rapidly progressive renal failure with serum creatinine levels of 6.5 mg/dL and blood urea of 98 mg/dL. Complete blood counts revealed a hemoglobin of 50 g/L, a leukocyte count of 13.3 3 10/L, and a platelet count of 46 3 10/L. Peripheral blood smear examination showed clusters of cells dispersed throughout the smear (panels A-D). These clusters wer...

Plasma cell leukemia is a rare disease entity where the number of clonal plasma cells in the peripheral blood exceeds 2X10 9 /l or 20% of the total leukocyte count. This plasma cell leukemia can be primary which is arising denovo or secondary as in the course of plasma cell myeloma. A 40 year old female who came to the outpatient department with complaints of low back pain for 3 months and had ...

post-remission treatment in patients with acute myeloid leukemia is still controversial. one potent choice for patients with no donor available is autologous stem cell transplantation. the median follow-up period was 18 months and the median age was 26 years old. in the review of 116 recently diagnosed aml patients (except aml- m3) who underwent autologous stem cell transplantation, 72.4% of pa...

Acute leukemia which is the most common cancer in children is a heterogeneous group of clonal malignancies. The conversion of the leukemic cell lineage during the course of the disease or later is termed lineage switch. It has been rarely reported in the literature. In leukemia lineage switch, conversions from lymphoblastic leukemia to myeloid leukemia or vice versa are reported. Herein, we rep...