Ghrelin, a gastric peptide hormone, has been reported to regulate GH secretion and energy homeostasis. Here, we examined the effect of des-acyl ghrelin driven from the fatty acid-binding protein-4 (FABP4) promoter on adiposity and glucose metabolism. A high level of expression of des-acyl ghrelin (692 +/- 293 fmol/g fat) in adipose tissue was detected in FABP4-ghrelin transgenic mice, but not i...

Ghrelin is a 28 amino acid peptide predominantly produced by the stomach that has been discovered to be a natural ligand of the orphan growth hormone (GH) secretagogue (GHS) receptor (GHS-R) type 1a. Like synthetic GHS, ghrelin possesses a strong GH-releasing effect provided that the molecule is acylated in serine3 and it is thought to be a natural GHS of major importance in the control of soma...

To investigate the effect of acylated ghrelin on the activation of TLR4/NF-κB signaling pathway induced by palmitic acid in human monocyte-derived (THP-1) macrophages, THP-1 macrophages were cultured for 12 h by palmitic acid with various concentrations. The THP-1 macrophages was pretreated by acylated ghrelin at different doses for 4 h before cultivated by palmitic acid (200 μmol/L) for 12 h. ...

Ghrelin is a circulating orexigenic hormone which is implicated in both the short-term control of food intake at single meals and in long-term body weight regulation. Due to the potent orexigenic action of this hormone, it would be expected that obese subjects would show elevated ghrelin levels that could contribute to pathogenesis of obesity. However, it was observed that ghrelin is downregula...

ghrelin increases food intakes and body weight. bombesin decreases food intakes and inhibits the stimulatory effect of ghrelin on food intakes. thyroid hormones have a crucial role in the regulation of body weight and yet the effect of bombesin on thyroid axis activity is not fully clear. therefore, the goal of this study was to determine the effect of different doses of ghrelin or bombesin on ...

Ghrelin increases food intakes and body weight. Bombesin decreases food intakes and inhibits the stimulatory effect of Ghrelin on food intakes. Thyroid hormones have a crucial role in the regulation of body weight and yet the effect of bombesin on thyroid axis activity is not fully clear. Therefore, the goal of this study was to determine the effect of different doses of Ghrelin or bombesin on ...

G hrelin, a growth hormone–releasing peptide that was first discovered in the stomach of rats in 1999, is an endogenous ligand of growth hormone secretagogue receptors (GHSRs). 1 Through binding to its receptors in the brain, ghrelin was initially shown to strongly stimulate the release of growth hormone and promote food intake. 2 Subsequent studies revealed that GHSRs are expressed ubiquitousl...

Ghrelin, a 28-amino acid acylated peptide, was identified as the endogenous ligand for the growth hormone (GH) secretagogue receptor and its role in reproduction has recently been established. It is believed that the site of ghrelin expression in testes may indicate its role in local regulation. This study investigated the immunohistochemical (IHC) localization of ghrelin in Holstein bull testi...

Ghrelin and obestatin are two proteins that originate from post-translational processing of the preproghrelin peptide. Various authors claim an opposed role of ghrelin and obestatin in several systems. Preproghrelin mRNA is significantly expressed in airway epithelium throughout lung development, predominantly during the earliest stages. The aim of this study was to evaluate the role of ghrelin...