Introduction Inflammation plays an important role in both atherosclerotic plaque progression and rupture [1], which has led to an interest in treatments with anti-inflammatory effects. To assess and monitor inflammation in vivo, dynamic contrast-enhanced (DCE) MRI has been previously demonstrated [2]. Kinetic parameters derived from DCE-MRI, including the transfer constant (K) and partial plasm...

BACKGROUND AND OBJECTIVE The subepithelial connective tissue graft (SCTG) is the most widely used procedure for the treatment of gingival recession defects. Little is known, however, as to whether the apposed gingival flaps are more predisposed to develop plaque-related inflammation compared to healthy sites. This has salient clinical implications, as the long-term results of root coverage will...

Background: Supragingival plaque control is fundamental to the prevention and management of periodontal diseases. However significant proportions of all individuals fail to practice a high standard of plaque removal. The adjunctive use of chemicals would, therefore appear a way of overcoming deficiencies in mechanical tooth cleaning habits. This prospective, randomized positively controlled cli...

Ghrelin has been found to be associated with anti-inflammatory effects, inhibition of atherosclerotic plaque formation, and plaque stability in the cardiovascular system. We investigated whether ghrelin affected atherosclerotic plaque and inflammation found in atherosclerosis. We crossed ghrelin receptor knock out mice (growth hormone secretagogue receptor (GHSR)-/-) and low-density lipoprotein...

We evaluated the association between oral health and mortality. The study population comprised 76,188 subjects aged 16-89 years at recruitment. The mean follow-up time was 3.4 ± 2.4 years. Subjects with a personal medical history of cancer or cardiovascular disease and death by casualty were excluded from the analysis. A full-mouth clinical examination was performed in order to assess dental pl...

OBJECTIVE To compare the therapeutic effects of the application of doxycycline-full dose (100 mg) and sub-dose (20 mg) in the treatment of periodontal disease. MATERIAL AND METHODS A total of 60 patients with periodontal disease were examined. Patients are divided into two groups: A) treated with antimicrobial dose of 100 mg doxycycline once daily for 30 days, and B) treated with 2 x 20 mg/da...

Introduction: Most acute coronary syndromes result from rupture of vulnerable plaques [1]. As a result, it’s clinically very important to assess the vulnerability of coronary plaque. While studies have shown that inflammation plays a major role in plaque rupture, it is crucial to be able to evaluate the extent of inflammation of coronary vessel wall plaque. Contrast-enhanced studies have shown ...

OBJECTIVE Lipids are central to the development of atherosclerotic plaques. Specifically, which lipids are culprits remains controversial, and promising targets have failed in clinical studies. Sphingolipids are bioactive lipids present in atherosclerotic plaques, and they have been suggested to have both proatherogenic and antiatherogenic. However, the biological effects of these lipids remain...

A rterial inflammation is the principal driving force responsible for atherosclerotic plaque development and destabilization. There is strong evidence that this inflammation is induced by the retention and oxidation of low-density lipo-protein (LDL) in the subendothelial space. Oxidized LDL is cytotoxic and may induce inflammation by causing arterial cell injury and by recruiting oxidized LDL-s...