Dupilumab was previously shown to reduce thymus and activation-regulated chemokine (TARC/CCL17) total IgE levels in multiple type 2 inflammatory diseases, including atopic dermatitis (AD). Here, we assess the effects of dupilumab treatment on these biomarkers inflammation children aged 6 months – 5 years with moderate-to-severe AD. In LIBERTY AD PRE-SCHOOL (NCT03346434 part B), a phase 3, doubl...

Anxiolytic drugs often have sedative effects that impair the ability to drive. Our double-blind, randomized crossover trial investigated effect of Silexan, a non-sedating, anxiolytic herbal medicinal product, on driving performance in healthy volunteers. Part 1 aimed at demonstrating equivalence between 80 mg/d Silexan and placebo. 2 was performed demonstrate superiority 160 320 mg over lorazep...

Placebo responses are highly variable across individuals. Explaining this variability is one of the keys to understanding endogenous regulatory processes, and is critical for measuring and controlling placebo effects in all kinds of studies. In this chapter, we review literature on the personality and brain correlates of individual differences in placebo analgesia. An emerging brain literature ...

Background: There is a knowledge gap in systematic reviews on the impact of opioid agonist treatments mental health.Objectives: We compared health outcomes between different and placebo/waitlist, opioids themselves.Methods: This meta-analysis randomized clinical trials (RCTs) was pre-registered at PROSPERO (CRD42018109375). Embase, MEDLINE, PsychInfo, CINAHL Complete, Web Science Core Collectio...

Abstract Background Patients with inflammatory bowel disease (IBD) treated immunomodulators or biological therapy are at increased risk of infections. Malnutrition and vitamin mineral deficiencies common among patients IBD. The results various studies have indicate that might increase the Methods Single-centre, randomized, double-blinded, placebo-controlled clinical trial to compare a multivita...

Background: Enthesitis is a key clinical domain and imaging hallmark of psoriatic arthritis (PsA). Ultrasound (US) highly sensitive tool for detecting synovitis enthesitis in PsA. The Outcome Measures Rheumatology Initiative (OMERACT) has developed an US definition scoring system studies. 1 ULTIMATE study ( NCT02662985 ) the first large double-blind (DB), placebo-controlled phase IIIb designed ...

conclusions premedication with clonidine to decrease intraoperative blood loss can be more effective in patients with opium addiction than the ones without addiction. results intraoperative blood loss in clonidine recipient groups, patients with and without addiction, was less than that of the placebos (both p values < 0.01) and the difference magnitude was higher in patients with opium addicti...

Acute myocardial infarction (MI) patients remain at high risk for recurrent events. Cholesterol efflux, mediated by apolipoprotein A-I, removes excess cholesterol from atherosclerotic plaque and transports it to the liver excretion. Impaired efflux is associated with higher cardiovascular (CV) event rates among both stable coronary artery disease recent MI. CSL112, a novel intravenous formulati...

BackgroundThe ExteNET trial demonstrated improved invasive disease-free survival (iDFS) with neratinib, an irreversible pan-HER tyrosine kinase inhibitor, versus placebo in patients human epidermal growth factor receptor 2-positive (HER2+)/hormone receptor-positive (HR+) early-stage breast cancer (eBC).Patients and MethodsExteNET was a multicenter, randomized, double-blind, phase III of 2840 HE...

Objective: Long term use of opioids and benzodiazepines are associated with important untoward effects. The α2 adrenergic agonist clonidine has sedative effects. Our goal was to study clonidine addition to total doses of fentanyl and midazolam and duration of ventilation in pediatric ICU (PICU). Methods: This randomized, double-blind, placebo-controlled trial was conducted in PICU of Mofi...