نتایج جستجو برای: pla2

تعداد نتایج: 1363  

Journal: :Antioxidants & redox signaling 2003
Rao Muralikrishna Adibhatla James F Hatcher Robert J Dempsey

Phospholipid degradation is an important promoter of neuronal death after transient cerebral ischemia. Phospholipid hydrolysis by phospholipase A2 (PLA2) after transient cerebral ischemia releases arachidonic acid. Arachidonic acid metabolism results in formation of reactive oxygen species, lipid peroxides, and toxic aldehydes (malondialdehyde, 4-hydroxynonenal, and acrolein). Citicoline (cytid...

Journal: :Gut 1997
M M Haapamäki J M Grönroos H Nurmi K Alanen M Kallajoki T J Nevalainen

BACKGROUND It has been suggested that phospholipase A2 (PLA2) has an essential role in the pathogenesis of inflammatory bowel diseases. AIMS This study aimed at identifying cells in intestinal and mesenteric tissue samples that might express group II phospholipase A2 (PLA2-II) at the mRNA and enzyme protein levels in patients with ulcerative colitis. PATIENTS AND TISSUE SAMPLES: Tissue sample...

2017
Ye Tian Huan Jia Sichen Li Yanmin Wu Li Guo Guojun Tan Bin Li

BACKGROUND Studies on stroke and lipoprotein-associated phospholipase A2 (Lp-PLA2) have produced conflicting results. OBJECTIVE The aim of the study was to assess the associations of Lp-PLA2 levels (mass and activity) with recurrent vascular events in patients with transient ischemic attack (TIA) and/or first ischemic stroke and with stroke in the general population. METHODS The MEDLINE, Em...

Journal: :The European journal of neuroscience 2001
K Arai Y Ikegaya Y Nakatani I Kudo N Nishiyama N Matsuki

Although it is well known that the hippocampal CA1 subfield is highly vulnerable to ischemic injury, cellular mechanisms leading to this neuronal degeneration are not fully understood. Using organotypic cultures of rat hippocampal slices, we determined whether phospholipase A2 (PLA2) is activated in response to ischemic conditions (OGD; oxygen and glucose deprivation). The PLA2 activity in the ...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2006
Frank D Kolodgie Allen P Burke Kristi S Skorija Elena Ladich Robert Kutys Addisalem Taye Makuria Renu Virmani

OBJECTIVE Although lipoprotein-associated phospholipase A2 (Lp-PLA2) has received recent attention as a biomarker of inflammation and risk for acute coronary events, its relative expression in coronary plaque phenotypes, including unstable lesions, has not been established. METHODS AND RESULTS Coronary segments (n=30) were prospectively collected from 25 sudden coronary death patients for imm...

Journal: :Maedica 2010
Manole Cojocaru Inimioara Mihaela Cojocaru Isabela Silosi

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a predictor biomarker for incident atherosclerotic disease. Lp-PLA2 has been identified in atherosclerotic plaques, however, its role in atherosclerosis is still under investigation. Lp-PLA2 belongs to the superfamily of phospholipase A2 enzymes. It is produced by macrophages that appears to play a role in the atherosclerotic vessel wall. Eme...

روحی بروجنی, حمید, هاشمی نیا, علی, پورقیصری, بتول ,

  B. Pourgheysari[1][2], A. Hasheminia[3], H. Rouhi-Boroujeni3   Received: 20/02/2014 Sent for Revision: 22/01/2014 Received Revised Manuscript: 09/10/2012 Accepted: 28/07/2012   Background and Objective: Venous thromboembolism (VTE) is one of the main causes of mortality in different human communities. Factor V Leiden, MTHFR C677T polymorphism and PLA2 polymorphism of platele...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1991
D Piomelli P Greengard

In preparations of synaptic terminals (synaptosomes) isolated from rat brain, the activity of phospholipase A2 (PLA2), a phospholipid hydrolase that serves a central function in signal transduction, was inhibited in a Ca(2+)-dependent manner by incubation with 60 mM K+ or with the Ca(2+)-selective ionophore ionomycin. Reversal by alkaline phosphatase treatment suggested that this inhibitory eff...

2015
Anping Cai Guang Li Jiyan Chen Xida Li Liwen Li Yingling Zhou

BACKGROUND Lipoprotein-associated phospholipase A2 (Lp-PLA2) plays complex and adverse roles on atherosclerosis. Current study was to investigate whether increased plasma Lp-PLA2 level is independently associated with the severity of coronary artery diseases (CAD). METHODS Totally 781 participants were enrolled and performed coronary angiography (CAG) to figure out the number of coronary arte...

Journal: :The Journal of biological chemistry 1998
R S Koduri S F Baker Y Snitko S K Han W Cho D C Wilton M H Gelb

Human group IIa phospholipase A2 (hIIa-PLA2) is a highly basic protein that is secreted from a number of cells during inflammation and may play a role in arachidonate liberation and in destruction of invading bacteria. It has been proposed that rodent group IIa PLA2 is anchored to cell surfaces via attachment to heparan sulfate proteoglycan and that this interaction facilitates lipolysis. hIIa-...

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