Hormones have been demonstrated to activate phosphoinositide hydrolysis in plasma membranes in a manner dependent upon or potentiated by GTP. For thyrotropin-releasing hormone activation in GH3 cell membranes, stimulation persisted in membranes from pertussis toxin-treated cells. These observations indicate the presence of a membrane phospholipase C (PL C) and a novel GTP-binding protein (Gp); ...

The molecular interactions between pancreatic lipase (PL) and four tea polyphenols (EGCG analogs), like (-)-epigallocatechin gallate (EGCG), (-)-gallocatechin gallate (GCG), (-)-epicatechin gallate (ECG), and (-)-epigallocatechin (EC), were studied from PL activity, conformation, kinetics and thermodynamics. It was observed that EGCG analogs inhibited PL activity, and their inhibitory rates dec...

Background. Anatomic variations, the presence of the pyramidal lobe (PL), may impact completeness of thyroidectomy and effect of surgical treatment. Method. This study included 166 patients who underwent total thyroidectomy. The anterior cervical region between the thyroid isthmus and the hyoid bone was dissected during thyroid surgery. The incidence, size, and anatomical features of the PL wer...

It was formerly demonstrated that PL retard and Choi accelerates the formation of tumours induced by M e C 2. This retardation respectively acceleration, however, never surpassed a period of somewhat more than four weeks. The question, then, arose why PL are only capable to retard temporarily and not to pre­ vent, i. e. retard permanently, the formation of tu­ mours. It was presumed that the ad...

We describe an algorithm to subdivide automatically a given set of PL nmanifolds (via coloured triangulations or, equivalently, via crystallizations) into classes whose elements are PL-homeomorphic. The algorithm, implemented in the case n = 4, succeeds to solve completely the PL-homeomorphism problem among the catalogue of all closed connected PL 4-manifolds up to gem-complexity 8 (i.e., which...

BACKGROUND Although several therapeutic options are currently available for patients with various cancers, the outcomes are often disappointing and a more effective modality needs to be promptly established. We have been exploring an alternative approach using natural agents and two bioactive mushroom extracts isolated from Phellinus linteus (PL), namely PL-ES and PL-I-ES, were of our interest....