Pituitary adenomas are usually benign neuroendocrine tumors. However, some of those that are histopathologically undistinguishable behave aggressively and metastasize. The polysialylated neural cell adhesion molecule (PSA-NCAM), which is highly expressed during the development of the brain and pituitary, is detected in some neuroendocrine tumors and might be relevant as a prognostic marker in p...

Pituitary adenomas are usually benign neuroendocrine tumors. However, some of those that are histopathologically undistinguishable behave aggressively and metastasize. The polysialylated neural cell adhesion molecule (PSA-NCAM), which is highly expressed during the development of the brain and pituitary, is detected in some neuroendocrine tumors and might be relevant as a prognostic marker in p...

background : central nervous system tumors account for 2%-5% of all malignancies in humans. these tumors account for 2% of all pediatric cancers. the worldwide incidence of primary central nervous system tumors is estimated at 3.9 (males) and 3.2 (females) per 100000 person-years. the incidence of brain tumor cases has been reported as 3.67% of all malignancies and 4% of all cancer mortalities ...

The co-existence of cerebral aneurysms and pituitary adenomas is rare. Here, we report a patient with a coexisting anterior communicating artery aneurysm and a pituitary adenoma and review the available literature concerning this phenomenon. There is a debate in the literature regarding any causal relationship between aneurysms and pituitary tumors, although there are many reports of aneurysms ...

Pituitary tumors, that origin from excessive proliferation of a specific subtype of pituitary cell, are mostly benign tumors, but may cause significant morbidity in affected patients, including visual and neurologic manifestations from mass-effect, or endocrine syndromes caused by hormone hypersecretion. Dopamine (DA) receptor DRD2 and somatostatin (SS) receptors (SSTRs) represent the main targ...

Aggressive pituitary tumors are rare but difficult to manage, as there is no effective chemotherapy to restrict their growth and cause their shrinkage. Within these tumors, growth-promoting cascades, like the PI3K/mTOR pathway, appear to be activated. We tested the efficacy of two inhibitors of this pathway, NVP-BKM120 (Buparlisib; pan-PI3K) and NVP-BEZ235 (dual PI3K/mTOR), both in vitro on imm...

<p>One of the common causes death is a brain tumor. Because above mentioned, early detection tumor critical for faster treatment, and therefore there are many techniques used to visualize One these magnetic resonance imaging (MRI). On other hand, machine learning, deep convolutional neural network (CNN) state art technologies in recent years solving medical image-related problems such as ...

Destruction of the thyroid gland by I's' in mice is followed by the development of TSH (thyroid stimulating hormone)-secreting pituitary tumors (5, 11, 13). These tumors can at first be grafted only on mice similarly radiothyroidectomized and not on normal animals (5) ; thus, they are initially conditioned or dependent growths. The tumor cells gain autonomy in the course of passages, as mdi cat...

carney’s complex is a rare autosomal dominantly inherited multiple endocrine neoplasia syndrome that involves spotty skin pigmentations, recurrent cardiac myxomas, endocrine hyperactivity, pituitary adenomas, peripheral nerve tumors, testicular tumors, and ovarian lesions. we present a case of sudden cardiac death in a 40 year old female with a history of carney’s complex with recurrent cardiac...