Possibilities of application of non-ionic surfactants of Rofam type as solubilizers for piroxicam poorly dissolved in water were assessed. Homologous series of Rofams containing oxyethylene segments from 3 to 18 were used in the study. Tablet formulation was made by wet granulation technique using these surfactants in order to improve drug dissolution properties. Influence of both quantity and ...

Biological effects of piroxicam, metamizol, and S-adenosylmethionine (S-AMET) have been tested in NMRI mice infected intraperitoneally with Trichomonas vaginalis. An intraperitoneal treatment during ten preinfection days with piroxicam (10 mg/Kg/day), or metamizol (275 mg/Kg/day), but not with S-AMET (117 mg/Kg/day) induced a significant decrease of abdominal lesions and mortality, assessed by ...

Over 90% of methylazoxymethanol acetate-treated male Lobund Sprague-Dawley rats developed intestinal tumors within 20 weeks; the incidence and numbers of tumors remained basically the same at 40 weeks. However, at week 40 the numbers of large tumors (greater than 0.5 cm in diameter) were increased. At week 40, tumors in methylazoxymethanol acetate-inoculated rats that had been treated with piro...

The objective of this work was to study the dissolution process from piroxicam pellets, coated with Eudragit RS 30 D by fluidized bed, in order to achieve an enteric release of the drug. The coating product contains a methacrylic copolymer which is insoluble, but permeable. The drug-loaded pellets were prepared by extrusionspheronization using microcrystalline cellulose (Avicel PH 101) as a sph...

This multicentre, randomized, open controlled study compared the local and overall tolerability of i.m. meloxicam with i.m. piroxicam in 211 patients with rheumatoid arthritis (RA) (n = 95) or osteoarthritis (OA) (n = 116). Of these, 210 patients were randomized (2:1) to receive meloxicam 15 mg (n = 144) or piroxicam 20 mg (n = 66) for 7 days. Local tolerability of meloxicam was significantly b...

Abstract Piroxicam is a popular anti-inflammatory drug that displays palliative and antipyretic activity. Peppermint oil common flavoring used in foods drinks. To investigate the defensive action of against hepatic renal histological damage induced by mice. Forty healthy adult Swiss albino mice both sexes were categorized into 4 groups (10 each group): Control group (I); Treatment (II) – inject...

The aim of this work was to study the in vitro release of piroxicam suspended in the internal phase of some W/O/W (water/oil/water) double emulsions and to investigate the effect of hydrophilic macromolecules (hydroxyethylcellulose and Carbopol 940) in the external aqueous phases of W/O/W double emulsions on the diffusion profiles of piroxicam through synthetic membranes. W/O/W double emulsions...

CYP2C9 wild-type protein has been shown to exhibit atypical kinetic profiles of metabolism that may affect in vitro-in vivo predictions made during the drug development process. Previous work suggests a substrate-dependent effect of polymorphic variants of CYP2C9 on the rate of metabolism; however, it is hypothesized that these active site amino acid changes will affect the kinetic profile of a...

The aim of this study was to develop and validate for determination of piroxicam in human plasma by new rapid HPLC method and to compare the relative bioavailability of two branded formulations of piroxicam in healthy Korean volunteers. The analysis running time of piroxicam was just 2 minutes using C 18 column (100 x 4.6 mm, 5 μm) with variable wavelength detector (at 355 nm). This HPLC method...