Reductive aminases (RedAms) have recently emerged as promising biocatalysts for the synthesis of chiral secondary amines by coupling primary with aldehydes/ketones. However, access to tertiary remains more problematic, particularly when ketones amines. Here we show that scope these enzymes can be extended allow selective reductive aminations cyclic amines, such piperidines and morpholines, both...

Many piperidine derivatives are found to possess pharmacological activity and form an essential part of the molecular structures of important drugs (Rubiralta et al., 1991; Venkatasa Perumal et al., 2001). Recently attention has been focussed on the application of the piperidone derivatives as prospective biophotonic materials (Nesterov et al., 2003; Sampathkumar et al., 2005). Since the pharma...

BACKGROUND The formation of novel N-substituted-1,2,3,4-tetrahydro[1,3]-dioxolo-[6,7]-5H-[1]benzopyrano [3,4-c]pyridines were observed unexpectedly during the acid-mediated ketal removal of ethylenedioxy ketal protected 4-piperidones. The literature revealed that benzopyranopyridine derivatives are of scientific interest and some exhibit interesting biological activities. Diastereomeric resolut...

Potenital pathways for the deactivation of hindered amine light stabilisers (HALS) have been investigated by observing reactions of model compounds--based on 4-substituted derivatives of 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO)--with hydroxyl radicals. In these reactions, dilute aqueous suspensions of photocatalytic nanoparticulate titanium dioxide were irradiated with UV light in the prese...

An easy and convenient microwave-assisted synthesis of a library of s-triazinyl piperazines and piperidines, which, in addition to 4-aminobenzonitrile contain 8-hydroxyquinoline is described. The newly synthesized analogues were then subjected to determine their efficacy against some human pathogenic bacterial and fungal strains as 3 Gram negative bacteria (K. pneumoniae, S. typhi, P. vulgaris)...

Abstract: In the course of the development of modem synthetic methods in the field of asymmetric synthesis the SAMP-/RAMP-hydrazone method opens a highly diastereoand enantioselective route to a great variety of carbonyl compounds, alcohols, amines and heterocycles. In this paper recent advances in the development of biomimetic C-C bond formations, such as the synthesis of C2-symmetric ketodiol...