In the title N-Mannich bases, 3-(adamantan-1-yl)-4-(4-fluoro-phen-yl)-1-[(4-phenyl-piperazin-1-yl)meth-yl]-4,5-di-hydro-1H-1,2,4-triazole-5-thione (C29H34FN5S) (I), and 3-(adamantan-1-yl)-4-(4-fluoro-phen-yl)-1-{[4-(2-meth-oxyphen-yl)piperazin-1-yl]-meth-yl}-4,5-di-hydro-1H-1,2,4-triazole-5-thione (C30H36FN5OS) (II), fluoro-phenyl, adamantane and piperazine moieties are linked to a planar triaz...

Purpose: Determination of the mutagenic potential of new biologically active compounds is of great concern for preliminary toxicity testing and drug development. Methods: The mutagenic and antimutagenic effects of some quinoline- and isoquinolinesulfonamide analogs of aripiprazole (1-8), which display potent antidepressant, anxiolytic, and antipsychotic properties, were evaluated using the Vibr...

In the title mol-ecular salt, C(5)H(13)N(2)O(2)S(+)·Cl(-), the complete cation is generated by crystallographic mirror symmetry, with both N atoms, the S atom and one C atom lying on the reflecting plane. The chloride ion also lies on the mirror plane. The piperazinium ring adopts a chair conformation and the N-S bond adopts an equatorial orientation. In the crystal structure, the component ion...

In the title compound, C(11)H(17)N(2)O(+)·Cl(-), the dihedral angle between the benzene ring and the basal plane of piperazine ring is 39.20 (8)°. In the crystal, intermolecular N-H⋯Cl hydrogen bonds occur. There is also a C-H⋯π inter-action between the benzene rings.

• Connections in Rn . We have by now defined a number of different notions of differentiation: the differential of maps between manifolds, the exterior derivative of differential forms, and the Lie derivative. To begin to see the need for a new notion of differentiation (which will turn out to be the most fundamental and will apply to general tensor fields) consider first the problem of definin...

In the present study, a biologically active 4-(trifluoromethyl)phenyl piperazin moiety was linked to a 2,2- dimethyl -2H-benzopyran template to generate (3R,4S)-2,2-dimethyl-6-nitro-4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl) chroman -3-ol (C110g), and the cellular and molecular mechanisms by which C110g exerts cytotoxic effects on the HeLa human cervical cancer cell line were further inves...

We survey recent results on the structure of the range of the derivative of a smooth mapping f between two Banach spaces X and Y . We recall some necessary conditions and some sufficient conditions on a subsetA of (X ,Y) for the existence of a Fréchet differentiable mapping f from X into Y so that f ′(X)= A. Whenever f is only assumed Gâteaux differentiable, new phenomena appear: for instance, ...

approximating the solution of differential equations of fractional order is necessary because fractional differential equations have extensively been used in physics, chemistry as well as engineering fields. in this paper with central difference approximation and newton cots integration formula, we have found approximate solution for a class of boundary value problems of fractional order. three...

potential field methods such as gravity and magnetic methods are among the most applied geophysical methods in mineral exploration. a high-resolution technique is developed to image geologic boundaries such as contacts and faults. potential field derivatives are the basis of many interpretation techniques. in boundary detection, the analytic signal quantity is defined by combining the val...