.................................................................................................. I SAMMANFATTNING ................................................................................... III LIST OF PAPERS ....................................................................................... V TABLE OF CONTENTS .........................................................................

BACKGROUND Negative pressure wound therapy (NPWT) is widely promoted as a treatment for full thickness wounds; however, there is a lack of high-quality research evidence regarding its clinical and cost effectiveness. A trial of NPWT for the treatment of grade III/IV pressure ulcers would be worthwhile but premature without assessing whether such a trial is feasible. The aim of this pilot random...

BACKGROUND Evidence suggests that systematic reviews are used infrequently by physicians in clinical decision-making. One proposed solution is to create filtered resources so that information is validated and refined in order to be read quickly. Two shortened systematic review formats were developed to enhance their use in clinical decision-making. METHODS To prepare for a full-scale trial, w...

When writing can change your life, when writing can enrich you by offering much money, why don't you try it? Are you still very confused of where getting the ideas? Do you still have no idea with what you are going to write? Now, you will need reading. A good writer is a good reader at once. You can define how you write depending on what books to read. This have we made progress the clinical pl...

Pilot power optimization in WCDMA networks is receiving increasing research attention. In this paper, we propose a mathematical programming approach for this problem. In particular, we present a novel mathematical formulation for minimizing pilot power subject to full coverage. In the formulation, the optimal power levels are determined simultaneously for all the cells. We further enhance the f...

Pilot studies for phase III trials - which are comparative randomized trials designed to provide preliminary evidence on the clinical efficacy of a drug or intervention - are routinely performed in many clinical areas. Also commonly know as "feasibility" or "vanguard" studies, they are designed to assess the safety of treatment or interventions; to assess recruitment potential; to assess the fe...