Angiogenesis refers to the process of new blood vessel formation that occurs during embryonal growth, wound healing, the menstrual cycle, and in certain diseases of the eye. Angiogenesis is also recognized as being critical for tumor growth, invasion and metastasis.1,2 The various steps of angiogenesis, such as basement membrane disruption, endothelial cell migration and proliferation, and tube...

Multiple myeloma (MM) progression closely depends on bone marrow (BM) angiogenesis. Several factors sustain angiogenesis, including cytokines, growth factors, and cell-to-cell interactions. Herein, BM thrombopoietin (TPO) was shown to support angiogenesis disease in MM. Patients with MM at different phases had higher levels of circulating TPO than monoclonal gammopathy undetermined significance...

Tumour development driven by inflammation is now an established phenomenon but the role that complement plays remains uncertain. Recent evidence has suggested that various components of the complement (C) cascade may influence tumour development in disparate ways; however, little attention has been paid to that of the membrane attack complex (MAC). This is despite abundant evidence documenting ...