Sir, Imatinib mesylate is a tyrosine kinase inhibitor that targets BCR-ABL protein in chronic myelogenous leukemia (CML).1 We present three cases of CML, treated with Imatinib who developed clinical findings of hypopigmentation. All the three patients noticed pigmentation changes after the initiation of therapy with Imatinib mesylate, which was persistent during therapy. The presence of hypopig...

Background: Neonates are presenting with various skin manifestations at birth or immediately after birth. Skin lesions in neonates can be physiological or pathological. Identification of physiological and pathological skin conditions with underlying associations helps in reassuring the parents or in the initiation of earlier interventions. Aim of the Study: To find out the prevalence of various...

Biodegradable HA composite systems based on PEOT/PBT have attracted much attention [1]. Making use of the reactivity of surface hydroxyl groups, PEOT/PBT [2] copolymers have been grafted to HA particles using diisocyanate coupling agents. This resulted in improved mechanical properties of composites. In this study, we set out to covalently bind 1000PEOT70PBT30 to HA by direct surface grafting v...

Segmenting sub-cortical structures from 3D brain images is of significant practical importance. This paper presents an experimental study for caudate segmentation in MRI images using a fully automatic algorithm based on [9], which is an extension of the hybrid model approach described in [1]. The method in [9] tackles multiple sub-cortical and cortical structures. In this study (the grand chall...

PURPOSE To describe our experience in infants with partial albinism and immunodeficiency (PAID), a rare, recently recognized, probably autosomal recessive disorder. PATIENTS AND METHODS Five infants suffering from this disease were examined with CT of the brain and four of these patients also underwent MR. Four of the five children also underwent follow-up CT or MR exams. RESULTS Three of t...

Hydrothermally synthesized acicular nano-apatite (Nap) was used as filler to make composites with a polyethylene glycol/poly(butylene terephthalate) (PEG/PBT) block copolymer (Polyactive 70:30). The Nap had a particle diameter of 9-25 nm and a length of 80-200 nm. The mechanical properties and the physiochemical characteristics of the composites, such as Young's modulus, swelling degree in wate...

We present a rare disease condition Hermansky-Pudlak syndrome in a 33-year-old male. He was born of a consanguineous marriage, had occulo-cutaneous albinism, nystagmus, decreased visual acuity, refractory errors, pulmonary fibrosis and granulomatous inflammation of the colon. In spite of all the classical features of this genetic disorder he was labeled to have disseminated tuberculous infectio...