In high-altitude climbers, the kidneys play a crucial role in acclimatization and in mountain sickness syndromes [acute mountain sickness (AMS), high-altitude cerebral edema, high-altitude pulmonary edema] through their roles in regulating body fluids, electrolyte and acid-base homeostasis. Here, we discuss renal responses to several high-altitude-related stresses, including changes in systemic...

Fifty-five successful experiments were performed on mongrel dogs weighing from 5 to 20 Kg. The procedure consists in the rapid intracarotid infusion toward the brain of physiologic saline solution, amounting to 2.3 times the estimated blood volume. This quantity is injected in three successive doses amounting to S5 per cent, SO per cent, and 65 per cent of the blood volume at intervals of 10 mi...

Spasm of the smooth muscle of the bronchi and bronchiole, edema of the mucosa leading to mucous collection, and occlusion of aveoli probably cause most of the symptoms of asthma. This resultant bronchial inflammation and obstructive emphysema may be acute, recurrent, or chronic. The degree to which these changes interfere with the passage of respiratory gases determined the severity of the cond...

Radiogenomics is a provocative new area of research based on decades of previous work examining the association between radiological and histological features. Many generalized associations have been established linking anatomical imaging traits with underlying histopathology, including associations between contrast-enhancing tumor and vascular and tumor cell proliferation, hypointensity on pre...

BACKGROUND Multiple studies have identified single variables or composite scores that help risk stratify patients at the time of acute lung injury (ALI) diagnosis. However, few studies have addressed the important question of how changes in pulmonary physiologic variables might predict mortality in patients during the subacute or chronic phases of ALI. We studied pulmonary physiologic variables...

OBJECTIVE Ginkgo biloba may have a role in treating impairments in memory, cognitive speed, activities of daily living (ADL), edema, inflammation, and free-radical toxicity associated with traumatic brain injury (TBI), Alzheimer's dementia, stroke, vasoocclusive disorders, and aging. The purpose of this review is to provide a synthesis of the mechanisms of action, clinical indications, and safe...

objective: to compare the effect of the physiologic and facilitated labor on the mother and neonate outcomes in the prim gravid women referring to arash hospital. materials and methods: this clinical trial study was performed on 200 low risk pregnant women referring to arash women's hospital in 2012-2013. mothers were divided into two groups of 100 patients using a simple random sampling method...

The generalized anatomic and physiologic immaturity of preterm infants of very low birth weight (VLBW) (<or=1,500 g) and extremely low birth weight (ELBW) (<or=1,000 g) places them at high risk for death or associated negative sequelae, including chronic lung disease of infancy (CLDI). The standard treatment for pulmonary immaturity, mechanical ventilation (MV) at birth, can lead to barotrauma,...

Growth of blood and lymphatic vessels is essential in the developing embryo and in the pathogenesis of human diseases such as cancer, but the signaling pathways that regulate vessel growth and function are not yet well characterized. In this issue of the JCI, studies by Fritz-Six et al. and Ichikawa-Shindo et al. demonstrate that loss of signaling by the adrenomedullin peptide results in embryo...