Recently, stimuli-responsive drug delivery systems (DDSs) with high spatial/temporal resolution bring many benefits to cancer treatment. However, cancer cells always develop ways to resist and evade treatment, ultimately limit the treatment efficacy of the DDSs. Here, we introduce photo-activated nanoliposomes (PNLs) that impart light-induced cytotoxicity and reversal of drug resistance in sync...

Liposomes are an effective gene and/or drug delivery system, widely used in biomedical applications including gene therapy and chemotherapy. Here, we designed a photo-responsive liposome (lipVP) loaded with a photosensitizer verteporfin (VP). This photosensitizer is clinically approved for photodynamic therapy (PDT). LipVP was employed as a DNA carrier for pituitary adenylyl cyclase-activating ...

In this paper, we propose a system to detect event photos using geotagged tweets and non-geotagged photo tweets. In our previous work, only “geotagged photo tweets” was used for event photo detection the ratio of which to the total tweets was very limited. In the proposed system, we use geotagged tweets without photos for event detection, and non-geotagged photo tweets for event photo detection...

Let bd(P ) denote the boundary of a simple polygon P . Points p and q of P are mutually visible if segment pq lies entirely inside P . This notion of visibility gave birth to an extensive literature on art-gallery problems [3], concerned with guarding the floor of a polygonal art-gallery. Chvatal [2] showed that bn/3c point guards are always sufficient and sometimes necessary. Allowing guards t...

Given the growth of Internet photo collections we now have a visual index of all major cities and tourist sites in the world. However, it is still a difficult task to capture that perfect shot with your own camera when visiting these places, especially when your camera itself has limitations, such as a limited field of view. In this paper, we propose a framework to overcome the imperfections of...

Imagine that you are the owner of several art galleries and that you are in the process of hiring people to guard one of them. Unfortunately, with so many in your possession, you seem to have forgotten the exact shape of this particular one. In fact, all you can remember is that the art gallery is a polygon with n sides. Of course, guards have the capacity to turn around a full 360◦ and can see...

We introduce the notion of a normal gallery, a gallery in which any configuration of guards that visually covers the walls necessarily covers the entire gallery. We show that any star gallery is normal and any gallery with at most two reflex corners is normal. A polynomial time algorithm is provided deciding if, for a given gallery and a finite set of positions within the gallery, there exists ...

Cancer is one of the major diseases affecting all humanity with high mortality rates worldwide. Its treatment difficult, long-term and expensive. Due to its side effects, it troublesome for both patient their attendants. basically divided into three: surgery, chemotherapy radiotherapy. Photodynamic therapy offers most important promising methods, especially in recent years. takes steps administ...