نتایج جستجو برای: phospholipase d pld

تعداد نتایج: 596477  

Journal: :FEBS letters 1999
J H Kim Y Kim S D Lee I Lopez R S Arnold J D Lambeth P G Suh S H Ryu

Although oleate has been implicated in the regulation of phospholipase D (PLD) activity, the molecular identity of the oleate-stimulated PLD is still poorly understood. We now report that oleate selectively stimulates the enzymatic activity of PLD2 but not of PLD1, with an optimal concentration of 20 microM in vitro. Intriguingly, phosphatidylinositol 4,5-bisphosphate (PIP2) synergistically sti...

Journal: :Journal of lipid research 2015
Rochelle K Nelson Michael A Frohman

Individual members of the mammalian phospholipase D (PLD) superfamily undertake roles that extend from generating the second messenger signaling lipid, phosphatidic acid, through hydrolysis of the membrane phospholipid, phosphatidylcholine, to functioning as an endonuclease to generate small RNAs and facilitating membrane vesicle trafficking through seemingly nonenzymatic mechanisms. With recen...

Journal: :Biochimica et biophysica acta 1997
M Madesh K A Balasubramanian

Intestinal mitochondria have a phospholipase D (PLD) activity which was stimulated by polyamines and monoamines resulting in the formation of phosphatidic acid (PA) from endogenous phospholipids. When stimulated by polyamines, mitochondrial PLD utilized endogenous phosphatidylethanolamine (PE) as substrate whereas stimulated by monoamines, both PE and phosphatidylcholine (PC) were hydrolysed. S...

Journal: :Plant physiology 2005
Chantal Vergnolle Marie-Noëlle Vaultier Ludivine Taconnat Jean-Pierre Renou Jean-Claude Kader Alain Zachowski Eric Ruelland

In plants, a temperature downshift represents a major stress that will lead to the induction or repression of many genes. Therefore, the cold signal has to be perceived and transmitted to the nucleus. In response to a cold exposure, we have shown that the phospholipase D (PLD) and the phospholipase C (PLC)/diacylglycerol kinase pathways are simultaneously activated. The role of these pathways i...

2013
Krutika Satish Gaonkar K. Balu Rituraj Purohit

bbreviations: RGS, Regulator rs compacta; mGluR, meta ini Spinny Neurons; LTD, L binoid; AMP, Adenosine Mo ; L-VGCCs, L-type voltage-g ide; PLD, phospholipase D arachidonoylglycerol; HADD in-protein DOCKing; CPOR esidues in Transient complex terface Residues in Transien otein-protein interaction inh ILES, Simplified molecular Corresponding author at: Hu izza 52, I-10126 Torino, Italy mail addre...

Journal: :Plant physiology 1997
L Xu S Zheng L Zheng X Wang

The expression of a castor bean (Ricinus communis L.) phospholipase D (PLD; EC 3.1.4.4) gene has been studied by examining its promoter activity in transgenic tobacco (Nicotiana tabacum) carrying a PLD promoter-glucuronidase transgene and by monitoring the levels of PLD mRNA in castor bean. Sequence and the 5' truncation analyses revealed that the 5' flanking region from nucleotide -1200 to -73...

2014
Julian Gomez-Cambronero

Phospholipase D (PLD) is a membrane protein with a double role: maintenance of the structural integrity of cellular or intracellular membranes and involvement in cell signaling through the product of the catalytic reaction, PA, and through protein-protein interaction with a variety of partners. Cross-talk during PLD signaling occurs with other cancer regulators (Ras, PDGF, TGF and kinases). Ele...

Journal: :The Journal of biological chemistry 1994
J Y Li K Hollfelder K S Huang M G Low

Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) is abundant in plasma and is potentially capable of degrading the anchor utilized by many cell surface proteins. The goal of this work was to study structural features of the GPI-PLD that might be involved in regulation of its activity. Trypsin cleaved the 100-110 kDa GPI-PLD polypeptide into three major fragments (two of approxima...

Journal: :The Biochemical journal 1999
M N Hodgkin J M Clark S Rose K Saqib M J Wakelam

Phospholipase D (PLD) activity has been shown to be GTP-dependent both in vivo and in vitro. One protein that confers GTP sensitivity to PLD activity in vitro is the low-molecular-mass G-protein ADP-ribosylation factor (Arf). However, members of the Rho family and protein kinase C (PKC) have also been reported to activate PLD in various cell systems. We have characterized the stimulation of PLD...

2011
Xuelin Han Rentao Yu Dongyu Zhen Sha Tao Martina Schmidt Li Han

The internalization of Aspergillus fumigatus into lung epithelial cells is a process that depends on host cell actin dynamics. The host membrane phosphatidylcholine cleavage driven by phospholipase D (PLD) is closely related to cellular actin dynamics. However, little is known about the impact of PLD on A. fumigatus internalization into lung epithelial cells. Here, we report that once germinate...

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