Lipid levels are commonly used in clinical settings as disease biomarkers, and the advent of mass spectrometry-based (MS) lipidomics heralds the possibility of identifying additional lipids that can inform disease predispositions. However, the degree of natural variation for many lipids remains poorly understood, thus confounding downstream investigations on whether a specific intervention is d...

Ethanolamine (Etn) is a naturally occurring aminoalcohol necessary for synthesis of the phospholipid phosphatidylethanolamine (PE), a major component of biological membranes. We recently reported that Etn treatment increases cellular PE levels, thereby inducing cytoprotective autophagy and protecting against aging across species.

A sphingomyelin-cleaving enzyme has been found in rat liver tissue. The enzyme, originally present in subcellular particulate fractions, could be released in a soluble form by treatment with appropriate detergents and was partially purified by conventional procedures. The most highly purified enzyme preparations catalyzed the hydrolysis of sphingomyelin, whereas lecithin and phosphatidylethanol...

BACKGROUND One of the most recognizable features of psychopathy is the reduced ability to successfully learn and adapt overt behavior. This might be due to deficient processing of error information indicating the need to adapt controlled behavior. METHODS Event-related potentials (ERPs) and behavioral components of error-monitoring processes were investigated in 16 individuals with psychopath...

Vesicles composed of a phosphatidylethanolamine derivative with a cyclopropyl-containing interfacial region are twenty-seven times less permeable than vesicles composed of a closely related analogue.

The acyl chain length, number, and distribution have been considered the major factors contributing to this biological activity of lipid A. The charged head groups on the dihexosamine backbone have also been implicated in contributing to this biology. In Neisseria, it has now been shown that loss of the 4' phosphoethanolamine has an impact on virulence in an animal model and on the organism's s...

This study investigates the effects of negative affect on performance monitoring. EEG was acquired during a lateralized, numeric Stroop working memory task that featured task-irrelevant aversive and neutral pictures between stimuli. Performance accuracy showed a right-hemisphere advantage for stimuli that followed aversive pictures. Response-locked event-related potentials (ERPs) from accurate ...