The acyl group of acyl dihydroxyacetone phosphate was shown to be enzymatically transferred in guinea pig liver mitochondria to various acceptors such as lysolecithin, lysophosphatidyl ethanolamine and sn-glycerol3-phosphate to form lecithin, phosphatidyl ethanolamine and phosphatidate, respectively. Coenzyme A and Mg*, but not ATP, were required for this reaction. A rapid exchange of acyl grou...

(2) The redirection of phosphatidate utilization probably partly explains the phospholipidosis which is observed after prolonged treatment with high doses of many cationic drugs. The drugs stimulate the synthesis of acidic lipids which are subsequently transported to the lysosomes with the drugs. The situation is probably aggravated further by an inability of the lysosomes to degrade this abnor...