spiro-4- thiazolidinones have been synthesized by the cyclocondensation of phthalazinyl hydrazones with cyclic ketones and substituted mercapto acetic acids. compounds were screened for their antibacterial, antifungal and antihypertensive activity. the combined elemental analyses and spectroscopic data prove the authenticity of the synthesized compounds

The pH-activated E/Z isomerization of a series of hydrazone-based systems having different functional groups as part of the rotor (R = COMe, CN, Me, H), was studied. The switching efficiency of these systems was compared to that of a hydrazone-based molecular switch (R = COOEt) whose E/Z isomerization is fully reversible. It was found that the nature of the R group is critical for efficient swi...

The title acyl-hydrazone derivative, C17H19N3O3S, containing an amino acid moiety and electron-donating substituents attached to both the phenyl rings, crystallized with two independent mol-ecules (A and B) in the asymmetric unit. The mol-ecules are bent at the S atom, with C-SO2-NH-CH2 torsion angles of -67.3 (2) and 67.7 (3)° in mol-ecules A and B, respectively. Further, the dihedral angles b...

The current study highlights the in vitro antioxidant and antitumor activity of the previously-synthesized hydrazone derivatives against various free radicals and human cancer cell lines, respectively. The anticancer efficacies of the compound were tested by measuring cytotoxicity in cancer cell lines HeLa, A549, and non-cancerous NL20 cells. Compounds possessing electron-donor methoxy and meth...

petroleum-polluted soil samples from ahvaz oilfield were enriched, using three methods to detect microorganisms with different dibenzothiophene degradation capabilities. strain nisoc-03, a nitrate-reducing, oxidase negative, catalase, citrate, and urease positive, gram negative rod, showed interesting dibenzothiophene desulfurization behavior, designated as entreobacter sp. strain nisoc-03 base...

Crystallizing the cobalt(II) salt of the azo dye Orange G from water was found to give the solvent-separated ion-pair species hexa-aqua-cobalt(II) 7-oxo-8-(2-phenyl-hydrazin-1-ylidene)-7,8-dihydro-naphthalene-1,3-disulfonate tetra-hydrate, [Co(H(2)O)(6)](C(16)H(10)N(2)O(7)S(2))·4H(2)O. The asymmetric unit of the cobalt(II) salt contains three independent octa-hedral [Co(OH(2))(6)](2+) cations, ...

Captan and folpet react with thiophenol in the presence of triethylamine in acetonitrile to form a bis (phenyl) trithiocarbonate which reacts with 2, 4dinitrophenyl hydrazine in the presence of hydrochloric acid to form corresponding hydrazone. The latter is transformed into an intense red quinoidal ion immediately on making solution alkaline. This observation have been made the basis of a simp...

The only small-molecule compound demonstrated to substantially extend survival in prion-infected mice is a biaryl hydrazone termed "Compd B" (4-pyridinecarboxaldehyde,2-[4-(5-oxazolyl)phenyl]hydrazone). However, the hydrazone moiety of Compd B results in toxic metabolites, making it a poor candidate for further drug development. We developed a pharmacophore model based on diverse antiprion comp...

Herein we describe NMR experiments and structural modifications of 4-methyl-2-phenylpyrimidine-N-acylhydrazone compounds (aryl-NAH) in order to discover if duplication of some signals in their ¹H- and ¹³C-NMR spectra was related to a mixture of imine double bond stereoisomers (E/Z) or CO-NH bond conformers (syn and anti-periplanar). NMR data from NOEdiff, 2D-NOESY and ¹H-NMR spectra at differen...