We herein aimed to evaluate the neuroprotective effects of resveratrol on a mouse model Parkinson’s disease and explore whether Wnt/beta-catenin signaling pathway was involved. Thirty male C57 black 6 mice were randomly divided into control group, group (1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine) treatment (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine resveratrol) (n=10). The groups intrape...

objective: it has been shown that deferasirox can reduce blood and tissues lead content in animal models. in this study the effect of deferasirox alone or combined with glycine as an antioxidant was evaluated in chronic cadmium toxicosis in rat. methods: male wistar albino rats were exposed to 200 ppm cadmium in the drinking water for 3 weeks and treated thereafter with deferasirox (140 mg/kg),...

Glycine, Alanine and Valine are taken as amino acids with an equal polar head and with thedifference in the length of hydrocarbon chains. The structural optimizations show the results of theisolated Glycine, Alanine and Valine in the gases phase, at the Hartree-Fock level by means ofSTO-3G,3-21G, 6-31G and 6-31+G basis sets. The calculations were performed for the ten (1-10)solvents using PCM m...

trans-Methyl styryl ketone (MSK; trans-4-phenyl-3-buten-2-one) is a beta-unsaturated ketone that has a wide range of uses in industry and is present in numerous consumer products. Although MSK has been shown to be positive in several in vitro mutagenic assays, it does not seem to be overtly toxic in animal models. This lack of toxicity may relate to its poor absorption and/or rapid elimination....

Reaction between aromatic aldehydes and 3–methyl-1-phenyl-2-pyrazoline-5-one catalyzed by nano-SiO2/HClO4 in water under reflux provided a simple and efficient route for the synthesis of 4-((5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)(aryl)methyl)-3-methyl-1-phenyl-1H-pyrazol-5-ol derivatives in high yields.

reaction of sodium salt of allyl alcohol with 2-chloro-5-phenyl- l,3,4-thiadiazole gave 2-allyloxy-5-phenyl-1,3,4-thiadiazole 2. compounds 4a and 4b could be obtained through the reaction of nitrone 3 with 2. reaction of compound 2 with nitrone 5 afforded the final compound 6. antifungal activity of all compounds was less than ketoconazole

Objective: It has been shown that deferasirox can reduce blood and tissues lead content in animal models. In this study the effect of deferasirox alone or combined with glycine as an antioxidant was evaluated in chronic cadmium toxicosis in rat. Methods: Male wistar albino rats were exposed to 200 ppm cadmium in the drinking water for 3 weeks and treated thereafter with deferasirox (140 mg/kg),...

the macrocyclic ligands 2,3,5,6-bis{3’-bromo-5’-tert-butyl benzo-5-phenyl benzo} 12c3 (l1), 2,3,5,6-bis{3’-bromo-5’-tert butyl-benzo-5’-phenyl-benzo}15c4 (l2), 2,3,5,6-bis{3’-bromo-5’-tert butyl-benzo-5’-phenyl-benzo}18c5 (l3) have been synthesized and their alkaline metal compounds with naclo4∙h2o and kclo4  have been prepared. chemical formulas of all compounds have been characterized by usin...