The chromodomain, helicase, DNA-binding protein 5 (CHD5) is a chromatin remodeling enzyme which is implicated in tumor suppression. In this study, we demonstrate the ability of the CHD5 PHD fingers to specifically recognize the unmodified N-terminus of histone H3. We use two distinct modified peptide-library platforms (beads and glass slides) to determine the detailed histone binding preference...

The proper timing of flowering is critical for successful reproduction. The perception of the seasonal cues of day-length changes and exposure to cold influences flowering time in many plant species through the photoperiod and vernalization pathways, respectively. Here we show that a plant homeodomain (PHD) finger-containing protein, VIN3-LIKE 1 (VIL1), participates in both the photoperiod and ...

The pattern of histone modifications, called the histone code, influences transitions between chromatin states and the regulation of transcriptional activity. Four recent papers describe how plant homeodomain (PHD) finger proteins read part of this code. The PHD finger may promote both gene expression and repression through interactions with trimethylated lysine 4 on histone 3 (H3K4), a univers...

Abstract Impostor syndrome (IS) refers to the inner speech of self-doubt and belief that you are not as competent others perceive be. The university can be considered a work environment prone IS, especially because requirements present higher education science policy, which emphasizes continuous evaluation, competitive spirit, focus on performance excellence. It is therefore understandable many...

This paper examines the challenges presented by PhD journey in internationalised environment of UK Higher Education and gives voice to experiences students. It focuses particularly on issue isolation marginalisation. Through semi-structured interviews with students supervisors at three institutions, it reveals that social interaction, lack academic community individualised nature supervisory re...