The qualification of biomarkers of drug safety requires data on many compounds and nonclinical and clinical studies. The cost and effort associated with these qualifications cannot be easily covered by a single pharmaceutical company. Intellectual property associated with safety biomarkers is also held by many different companies. Consortia between different pharmaceutical companies can overcom...

Africa has the highest disease burden in the world and continues to depend on pharmaceutical imports to meet public health needs. As Asian manufacturers of generic medicines begin to operate under a more protectionist intellectual property regime, their ability to manufacture medicines at prices that are affordable to poorer countries is becoming more circumscribed. The Doha Declaration on the ...

Recent global developments in the regulation of trade and intellectual property rights threaten to hinder the access of populations in developing countries to essential drugs. The authors argue for state intervention in the health and pharmaceutical markets in order to guarantee equitable access to these products.

The economic theory of property rights is applied to the issue of the conservation of plant genetic diversity, an issue often discussed in terms of benefit sharing, in order to demonstrate that the assignment of property rights is important for reasons of efficiency as well as for equity. Given the existence of transaction costs within an industry, the location of a property rights assignment i...

The economic theory of property rights is applied to the issue of the conservation of plant genetic diversity, an issue often discussed in terms of benefit sharing, in order to demonstrate that the assignment of property rights is important for reasons of efficiency as well as for equity. Given the existence of transactions costs within an industry, the location of a property rights assignment ...

Intellectual property (IP) is a hot issue now, just as land as property was 400 years ago with the beginning of capitalism. Does this mean that we are indeed in a new phase of modernity, in which knowledge is becoming a commodity? The international struggles over IP started, however, with very different stakeholders, like worlddominating governments and huge (mostly pharmaceutical) companies. W...

Millions of people lack access to affordable medicines. The intellectual property rules in the Central America Free Trade Agreement (CAFTA) provide pharmaceutical companies with monopoly protections that allow them to market some drugs without competition by less costly generics. We examined availability of certain drugs in Guatemala and found that CAFTA intellectual property rules reduced acce...

Molecular discovery often involves identification of the best functional groups (substituents) on a scaffold. When multiple substitution sites are present, the number of possible substituent combinations can be very large. This article introduces a strategy for efficiently optimizing the substituent combinations by iterative rounds of compound sampling, substituent reordering to produce the mos...

The World Trade Organisation's Trade Related Intellectual Property Rights [TRIPS] agreement aimed to harmonise intellectual property rights and patent protection globally. In India, the signing of this agreement resulted in a sharp increase in clinical trials since 2005. The Indian government, along with larger Indian pharmaceutical companies, believed that they could change existing commercial...