نتایج جستجو برای: pgj2
تعداد نتایج: 308 فیلتر نتایج به سال:
Cyclopentenone prostaglandins (cyPG) with antiinflammatory and antiproliferative properties have been envisaged as leads for the development of therapeutic agents. Because cyPG effects are mediated in part by the formation of covalent adducts with critical signaling proteins, it is important to assess the specificity of this interaction. By using biotinylated derivatives of 15-deoxy-D-PGJ2 (15d...
Induced Gene Expression − α Human Vascular Endothelial Cells : The Effect of 15d-PGJ2 on Tumor Necrosis Factorin γ Activated Receptor− but Not Peroxisome Proliferator α Related Orphan Receptor− (15d-PGJ2) Signals Through Retinoic Acid Receptor 2 -Prostaglandin J 12,14 ∆ 15-DeoxyPrint ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2005 American Heart Association, Inc. All rights reserved. G...
Oxidative stress and inflammation are two major contributing factors to atherosclerosis, a leading cause for cardiovascular diseases (CVDs). Oxidation of phospholipids on the surface of low density lipoprotein (LDL) particles generated http://www.jbc.org/cgi/doi/10.1074/jbc.M116.751909 The latest version is at JBC Papers in Press. Published on February 15, 2017 as Manuscript M116.751909 Copyrig...
BACKGROUND Peroxisome proliferator-activated receptor-gamma (PPARγ) is a ligand-activated transcription factor that exerts multiple biological effects. Growing evidence suggests that PPARγ plays an important role in inflammation; however, the effects of this transcription factor on the inflammation caused by smoking are unclear. METHODS We measured the expression of inflammatory cytokines (le...
Migration of vascular smooth muscle cells (VSMCs) plays an important role in atherogenesis and restenosis after arterial interventions. The expression of matrix metalloproteinases (MMPs), particularly MMP-9, contributes to VSMC migration. This process requires degradation of basal laminae and other components of the arterial extracellular matrix. Peroxisome proliferator-activated receptors (PPA...
The relative inhibitory potency of prostaglandin A (PGA) and prostaglandin J2 (PGJ2) analogues compared to prostaglandin A1 (PGA1) was determined in a clonogenic assay system. Three human melanoma cell strains (C8146A, C8146C, and C8161), a human melanoma cell line (M1RW5) and a human neuroblastoma cell line (IMR-32) were used. Prostaglandin analogues were screened in the clonogenic assay syste...
Inhibition of the proliferation of transformed epidermal cells in culture by various prostaglandins.
Cytotoxic action of various prostaglandins (PGs) was examined on the PAM 212 transformed mouse epidermal cell line, and delta 7-PGA1 was found most active. delta 7-PGA1 exerted a dose-dependent inhibition of PAM 212 cell growth over 0.1 microgram/ml (0.3 microM). At 1.6 microgram/ml (4.6 microM) growth was completely inhibited, and the number of viable cells decreased remarkably during culture....
Cancer chemopreventive agents transcriptionally induce glutathione S-transferase (GST), which can protect cells from chemical-induced carcinogenesis. Activation of either NF-E2-related factor-2 (Nrf2) or the CCAAT/enhancer binding protein-beta (C/EBPbeta) contributes to GST induction. Peroxisome proliferator-activated receptor-gamma (PPARgamma) and the retinoic acid X receptor (RXR) play roles ...
Prostaglandins (PG) are detected in virtually all organs and cells, whereas their enhanced release follows inflammatory mechanisms. PG synthesis, especially of PGE2, PGD2 and PGF2a, also takes place in epidermal keratinocytes as a result of arachidonic acid (AA) metabolism (Kondoh et al, 1985; Pentland and Needleman, 1986) and is differentially supported by specific enzymatic systems, the const...
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