نتایج جستجو برای: pgi
تعداد نتایج: 1108 فیلتر نتایج به سال:
Phosphoglucose isomerase/autocrine motility factor (PGI/AMF) plays an important role in glycolysis and gluconeogenesis and is associated with invasion and metastasis of cancer cells. We have previously shown its role in the induction of epithelial-mesenchymal transition (EMT) in breast cancer cells, which led to increased aggressiveness; however, the molecular mechanism by which PGI/AMF regulat...
سابقه و هدف: گزارش های قبلی نشان داده اند که استفاده از عصاره گیاه بابونه همراه با مرفین، وابستگی به مرفین را به میزان زیادی کاهش می دهد و تزریق آن قبل از نالوکسان، از بروز سندرم ترک جلوگیری می کند. هسته های لکوس سرولئوس (Lc) و پاراژیگانتوسلولاریس (PGi) در بروز علایم ترک اعتیاد نقش مهمی دارند. این مطالعه به منظور تعین اثرات تزریق عصاره بابونه به درون هسته پاراژیگانتوسلولاریس مغز بر علایم قطع مص...
Background: Fatigue is often identified as weakness following muscular exertion in patients with multiple sclerosis (MS) but may be associated with other physical, cognitive and emotional symptoms. Objective: To develop a Spanish language global impression of fatigue scales to evaluate symptoms of fatigue distinct from a particular disease. Methods: 50 ambulatory patients with MS attending a cl...
OBJECTIVES The purpose of this paper is to elucidate the roles of phospholipase A(2) (PLA(2)), cyclooxygenase-2 (COX-2), and prostaglandin I(2) (PGI(2)) synthase in pregnancy induced hypertension (PIH). METHODS In placentas from normal pregnant women and pregnant women with severe PIH, the enzyme expression of PLA(2), COX-2, and PGI(2) synthase was measured using real time reverse transcripti...
in this study the effect of adenosine and caffeine on spontaneous activity of paragigantocellularis (pgi) neurons was investigated. the spontaneous activity of pgi neurons was significantly decreased by microinjection of adenosine (10 nm, 0.5 µl) into pgi nucleus of both control and morphine-dependent rats. the decrease in firing rate of pgi neurons of morphine-dependent rats was greater than t...
OBJECTIVE The present study was designed to investigate the role of protein kinase C (PKC) and phospholipase D (PLD) in angiotensin II (AngII)- and phorbol ester (PMA)-induced cyclooxygenase-2 (COX-2) expression and prostacyclin (PGI(2)) production in rat aortic smooth muscle cells (VSMC). METHODS Prostacyclin production in cultured VSMC was determined by radioimmunoassay. PKC activity was ex...
Nitroglycerin (NTG), the agent most commonly used to treat acute angina pectoris, is a vasodilator whose mechanism of action remains unknown. We hypothesized that NTG might induce endothelial cells to synthesize prostacyclin (PGI(2)), a known vasodilator and inhibitor of platelet aggregation. Therefore, cultured human endothelial cells were incubated with NTG at various concentrations for 1-3 m...
Enzymes from females of five Pratylenchus brachyurus populations and one P. scribneri population were analyzed by isoelectric focusing electrophoresis. Of the 18 enzyme systems investigated, only malate dehydrogenase (MDH), phosphoglucomutase (PGM), and phosphoglucose isomerase (PGI) were detected from all five P. brachyurus populations and P. scribneri. Faint bands were detected for isocitrate...
آنزیم آلکالن فسفاتاز سرم انسانی از پروتئین های دایمر حاوی یون های فلزی mg و zn بوده وکه وزن مولکولی آن kd 130 در حالت گلیکوزیله می باشد. از حیث فارماکولوژی، داروهای زیادی بر عملکرد alp اثر و باعث افزایش سطح سرمی آن در بدن می شوند. به این علت مطالعه آنزیم ها به ویژه alp، در آزمایشگاه می تواند الگوی مناسبی برای طراحی داروهای جدید و مطالعه نحوه اثر آنها باشد. میزان آنزیم آلکالن فسفاتاز در سرم انسا...
The cellular events that serve to regulate lung mucosal Th2 responses and limit allergic inflammatory reactions are unclear. Using the DO11.10 TCR transgenic mouse, we developed a model of T cell-mediated pulmonary inflammation and demonstrated that high levels of PGI(2) are produced in the airways following OVA inhalation. Selective inhibition of cyclooxygenase-2 in vivo specifically reduced P...
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