Background & objective: Perioperative shivering after spinal anesthesia for cesarean section is a common and unpleasant complication. Currently pethidine being used but the search continues to look other agents with faster action fewer side effects. Tramadol potential anti-shivering drug modulation of central thermoregulation.
 We compared efficacy tramadol versus in treatment perioper...

objectives this study aimed to assess the efficacy and safety of intramuscular pethidine as an analgesic during labor by comparing it to inhaled 50% nitrous oxide (entonox). conclusions inhaled nitrous oxide seems to give better pain relief in the short term compared to a single dose of pethidine. entonox, which is more convenient to administer than an intramuscular injection of pethidine, is a...

There has been a recent renewal of interest in the use of monoamine oxidase inhibitors in psychiatry. The concurrent administration of anaesthetic agents, particularly narcotic analgesics, is often a cause for concern. Although many monoamine oxidase inhibitor-drug interactions have been reported, in practice it is only the interaction with pethidine which has led to fatalities. What is not app...

This study was performed to assess the severity and duration of hypoxia during and after prolonged upper gastrointestinal endoscopy. Twenty patients were studied using a non-invasive pulse oximeter. Significant reductions in oxygen saturation were noted during endoscopy and remained below the preexamination level during the one hour period after the examination. This study indicates that pulse ...

The use of opioids is often associated with less pain but more suffering in terms of unwanted side effects, some of which may lead to significant morbidity and even mortality. In an attempt to address this problem, numerous alterations were made to the original molecules found in the opium plant. Among others, heroin, methadone and the phenylpiperidine derivatives (fentanyl, pethidine, etc.) we...

Pentazocine and pethidine have been compared in the dose ratio 45:75 for their depression of respiration in normal subjects. The respective additive actions of the two drugs were investigated by comparing the effects of a single dose with those of two repeated half-doses. Some degree of ventilatory depression was found consistently. A first half-dose of pentazocine 22.5 mg had a greater effect ...