The aim of this study was to ascertain the effect different solvents on extraction yield, antioxidant activity and cytotoxicity extracts from Petasites japonicus (Siebold & Zucc.) Maxim. P. japonicus, widely distributed in Korea, Japan China, is used as a culinary vegetable traditional medicine for asthma, migraines tension headaches, allergic rhinitis. In study, twelve leaves, petiole...

Migraine is one of the most frequent disabling neurological conditions with a major impact on the patients' quality of life. To give evidence-based or expert recommendations for the different drug treatment procedures of the different migraine syndromes based on a literature search and an consensus in an expert panel. All available medical reference systems were screened for all kinds of clinic...

OBJECTIVES To compare the efficacy and tolerability of butterbur (Petasites hybridus) with cetirizine in patients with seasonal allergic rhinitis (hay fever). DESIGN Randomised, double blind, parallel group comparison. SETTING Four outpatient general medicine and allergy clinics in Switzerland and Germany. PARTICIPANTS 131 patients were screened for seasonal allergic rhinitis and 125 pati...

OBJECTIVE Although a wide range of acute and preventative medications are now available for the treatment of migraine headaches, many patients will not have a significant improvement in the frequency and severity of their headaches unless lifestyle modifications are made. Also, given the myriad side effects of traditional prescription medications, there is an increasing demand for "natural" tre...

Calcitonin gene-related peptide (CGRP) is a pivotal messenger in the inflammatory process in migraine. Limited evidence indicates that diet impacts circulating levels of CGRP, suggesting that certain elements in the diet may influence migraine outcomes. Interruption of calcium signaling, a mechanism which can trigger CGRP release, has been suggested as one potential route by which exogenous foo...

Quercetin is one of the six subclasses of flavonoid compounds1, which has antioxidant properties2. Quercetin is found in many common foods including green tea1, apples, onions and berries3. Its structure with the indicated C atoms and rings is presented in Figure 1. Because of its interesting chemical and biological properties, quercetin has been one of the most studied flavonoids. Quercetin is...