Noninvasive imaging in the evaluation of a wide variety of cardiovascular diseases has gained an increasing role in the diagnostic strategy in current cardiology practice [1–4]. This holds in particular for patients with myocardial ischaemia due to coronary artery disease (CAD) [5–7]. Of the present imaging modalities, single-photon emission computed tomography (SPECT), positron emission tomogr...

Multi-modality imaging provides coregistered PET-CT and SPECT-CT images; however such multi-modality workflows usually consist of sequential scans from the individual imaging components for each modality. This typical workflow may result in long scan times limiting throughput of the imaging system. Conversely, acquiring multi-modality data simultaneously may improve correlation and registration...

Over the last 20 years, SPECT and PET, along with CT and MRI have been the main methodologies used in studies investigating psychiatric disorders. The structural alterations in patients’ brains found by CT and MRI are usually quite subtle, while those found by the nuclear imaging modalities (PET and SPECT) are more pronounced. Partly for this reason, the latter methods have led to discoveries i...

Single photon emission computed tomography (SPECT) and positron emission tomography (PET) are functional nuclear medicine techniques which allow for accurate non-invasive in vivo measurements of a wide range of regional tissue functions in man. Brain functional imaging with SPECT and PET is based on the recording of the distribution of administered radionuclides in three dimensions, thus produc...

In the rapidly changing world of medicine, boundaries between specialties are constantly being challenged. Fused and hybrid imaging with integration of single photon emission computed tomography (SPECT) and computed tomography (CT)(SPECT/ CT) and positron emission tomography (PET) and CT (PET/CT), represent an area of very rapid growth with significant implications for the medical profession. S...

SPECT has traditionally been regarded as nonquantitative. Advances in multimodality γ-cameras (SPECT/CT), algorithms for image reconstruction, and sophisticated compensation techniques to correct for photon attenuation and scattering have, however, now made quantitative SPECT viable in a manner similar to quantitative PET (i.e., kBq cm(-3), standardized uptake value). This review examines the e...

INTRODUCTION A physical 3-dimensional phantom that simulates PET/SPECT images of static regional cerebral blood flow in grey matter with a realistic head contour has been developed. This study examined the feasibility of using this phantom for evaluating PET/SPECT images. METHODS The phantom was constructed using a transparent, hydrophobic photo-curable polymer with a laser-modelling techniqu...

PURPOSE The role of fusion imaging methods SPECT-CT and PET-CT is currently being investigated in radiotherapy (RT) treatment planning. SPECT and PET provide extra information for gross tumor volume (GTV) delineation. The purpose of this study was to evaluate the role of SPECT-CT in RT. METHODS SPECT-CT studies were performed in 55 patients with (99m)Tc-MIBI/Tetrofosmin (TF), with 99mTc-Nanoc...

The dopamine transporter (DAT) is a transmembrane protein responsible for reuptake of dopamine from the synaptic cleft and termination of dopaminergic transmission. Several radioligands are available for DAT imaging with SPECT and PET. This review summarizes the main SPECT and PET radioligands and the main applications of DAT imaging in neuropsychiatric disorders.

Radiolabeled liposomes have been employed as diagnostic tools to monitor in vivo distribution of liposomes in real-time, which helps in optimizing the therapeutic efficacy of the liposomal drug delivery. This work utilizes the platform of [111In]-Liposome as a drug delivery vehicle, encapsulating a novel 18F-labeled carboplatin drug derivative ([18F]-FCP) as a dual-molecular imaging tool as bot...