BACKGROUND The widespread use of organophosphorus (OP) pesticides has led to frequent exposure in adults and children. Because such exposure may cause adverse health effects, particularly in children, the sources and patterns of exposure need to be studied further. OBJECTIVES We assessed young urban/suburban children's longitudinal exposure to OP pesticides in the Children's Pesticide Exposur...

Children are exposed to a wide variety of pesticides originating from both outdoor and indoor sources. Several studies were conducted or funded by the EPA over the past decade to investigate children's exposure to organophosphate and pyrethroid pesticides and the factors that impact their exposures. Urinary metabolite concentration measurements from these studies are consolidated here to identi...

Background: The organochlorine DDT has estrogenic activity but the mechanism underlying the estrogenic activity of this pesticide remains unclear. In the present investigation here, we studied the transcriptional effects of a synthetic organochlorine pesticide o,p’-DDT [1.1.1.-trichloro-2-(o-chlorophenyl)-2-p-chloriphenyl ethane] and its metabolite p,p'-DDE (2-2-bis(4/chlorophenyl)-1-1-di...

The stereoselective difference of chiral pesticide enantiomers is an important factor risk evaluation and the subject has received wide attention. In present work, enantioselective metabolism phenylpyrazole insecticides including fipronil, ethiprole flufiprole in rat liver microsomes was investigated vitro. result showed remarkable enantioselectivity for fipronil with EF values 0.11–0.58. metab...

Given extensive use of pesticides in agriculture, there is concern for unintended consequences to non-target species. The freshwater amphipod, Hyalella azteca has been found show resistance the organophosphate (OP) pesticide, chlorpyrifos, resulting from an amino acid substitution acetylcholinesterase (AChE), suggesting a selective pressure pesticide exposure. Since resistant organisms can surv...