نتایج جستجو برای: permeability flux

تعداد نتایج: 135274  

Journal: :The Journal of General Physiology 1978
J Gutknecht J S Graves D C Tosteson

The permeability properties of planar lipid bilayers made from egg lecithin, n-decane and a long-chain secondary amine (n-lauryl [trialkylmethyl]amine) are described. Membranes containing the secondary amine show halide selectivity and high conductance at pH less than 6, as estimated by measurements of zero-current potentials generated by NaBr activity gradients. In the absence of halide ions, ...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2007
Mélanie G Gareau Jennifer Jury Mary H Perdue

Neonatal maternal separation (MS) predisposes adult rats to develop stress-induced mucosal barrier dysfunction/visceral hypersensitivity and rat pups to develop colonic epithelial dysfunction. Our aim was to examine if enhanced epithelial permeability in such pups resulted from abnormal regulation by enteric nerves. Pups were separated from the dam for 3 h/day (days 4-20); nonseparated (NS) pup...

Journal: :Journal of the American Society of Nephrology : JASN 1991
H W Harris

Antidiuretic hormone (ADH) dramatically increases the water permeability of toad urinary bladder by insertion of unique highly selective water channels into the apical membranes of granular cells. Before ADH stimulation, water channels are stored in high concentrations in the limiting membranes of large cytoplasmic vesicles called aggrephores. ADH stimulation causes aggrephore fusion with the g...

Journal: :American journal of physiology. Cell physiology 2005
Warren G Hill Eyad Almasri W Giovanni Ruiz Gerard Apodaca Mark L Zeidel

Caveolae are invaginated membrane structures with high levels of cholesterol, sphingomyelin, and caveolin protein that are predicted to exist as liquid-ordered domains with low water permeability. We isolated a caveolae-enriched membrane fraction without detergents from rat lung and characterized its permeability properties to nonelectrolytes and protons. Membrane permeability to water was 2.85...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2007
Timo Korjamo Heidi Kemiläinen Aki T Heikkinen Jukka Mönkkönen

Passive permeability and active efflux are parallel processes in transcellular flux. Therefore, the observed kinetics of a transporter substrate depends on both of these factors. The transporter expression has been shown to affect both the apparent K(m) and V(max) values. Kinetic parameters can be obtained from various experimental settings, but these do not necessarily reflect the situation in...

Journal: :The Journal of General Physiology 2000
Erik Hviid Larsen Jakob Balslev Sørensen Jens Nørkær Sørensen

A mathematical model of an absorbing leaky epithelium is developed for analysis of solute coupled water transport. The non-charged driving solute diffuses into cells and is pumped from cells into the lateral intercellular space (lis). All membranes contain water channels with the solute passing those of tight junction and interspace basement membrane by convection-diffusion. With solute permeab...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1999
E Bucha R Kreml G Nowak

BACKGROUND After introducing the specific thrombin inhibitor recombinant hirudin (r-hirudin) into clinical practice in cases of heparin-induced thrombocytopenia (HIT, type II) the possibility of its use as an anticoagulant during haemodialysis treatment in HIT II patients is being discussed more frequently. On the one hand, the efficient, safe and routine use of r-hirudin during haemodialyses, ...

Journal: :Investigative ophthalmology & visual science 2011
Jennifer L Kielczewski Sergio Li Calzi Lynn C Shaw Jun Cai Xiaoping Qi Qing Ruan Lin Wu Li Liu Ping Hu Tailoi Chan-Ling Robert N Mames Sue Firth Robert C Baxter Patric Turowski Julia V Busik Michael E Boulton Maria B Grant

PURPOSE To examine the effect of free insulin-like growth factor (IGF) binding protein-3 (IGFBP-3), independent of the effect of insulin-like growth factors, in modulating retinal vascular permeability. METHODS We assessed the ability of a form of IGFBP-3 that does not bind IGF-1 (IGFBP-3NB), to regulate the blood retinal barrier (BRB) using two distinct experimental mouse models, laser-induc...

Journal: :Endocrinologia japonica 1974
M Ando

Transepithelial potential difference (PD) and net water flux were estimated simultaneously in the posterior part of the intestine isolated from Japanese eels with special reference to the role of cortisol in the sea-water adaptation of the intestine. When cortisol was previously injected into freshwater eels, the serosa negativity of the PD, water flux and osmotic permeability (Po) increased at...

Journal: :The Journal of General Physiology 1972
Patrick Eggena

Toad bladders were challenged with vasopressin at one temperature, fixed on the mucosa with 1% glutaraldehyde, and then subjected to an osmotic gradient at another temperature. Thus, the temperature dependence of vasopressin action on membrane permeability was distinguished from the temperature dependence of osmotic water flux. As the temperature was raised from 20 degrees to 38 degrees C, ther...

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