Macrocyclic peptides are a promising class of compounds that can often engage challenging therapeutic targets. Display technologies, such as mRNA display, allow for the efficient discovery macrocyclic peptides. This article reviews current approaches generating peptide libraries using display and highlights some recent examples ribosomal incorporation nonproteinogenic amino acids into

background: amylin and salmon calcitonin belong to the calcitonin family of peptides and have high affinity binding sites in the rat spinal cord. the aim of this study was to characterize receptors for amylin and salmon calcitonin functionally in the spinal cord of rats. we assessed the expression of c-fos in response to intraplantar formalin in the lumbar regions of the spinal cord in consciou...

β-peptides are peptide-mimetics with wide biomedical and biotechnological applications. Their most peculiar feature is their readiness to fold into various secondary structures not found in natural counterparts. Furthermore, β-amino acid insertions polypeptides were provide unique features also increase enzymatic stability. This due the additional methylene group backbone, which on other hand m...

Scorpions are generally an important source of bioactive components, including toxins and other small peptides as attractive molecules for new drug development. Mesobuthus eupeus, from medically important and widely distributed Buthidae family, is the most abundant species in Iran. Researchers are interesting on the gland of this scorpion due to the complexity of its venom. Here, we have analyz...

Membrane fusion plays a vital role in several biological processes such as cellular uptake, communication between cells and RNA delivery. Due to its complexity, model membranes minimalistic protein models are often used gain insight into the process. Coiled–coil (CC) peptides, consisting of two five α–helical highly advantageous models. One most common CC complex is formed complementary peptide...

Poly glutamine and glutamine-rich peptides play a central role in plethora of pathological aggregation events. However, biophysical characterization soluble oligomers -the most toxic species involved these processes- remains elusive due to their structural heterogeneity dynamical nature. Here, we exploit the high spatio-temporal resolution coarse-grained simulations as computational microscope ...

Efforts to express lipase in the periplasmic space of Escherichia coli have so far been unsuccessful andmost of the expressed recombinant lipases accumulate in the insoluble cell fraction. To evaluate the role ofnative and heterologous signal peptides in translocation of the lipase across the inner membrane of E. coli,the lipase gene (btl2) was cloned downstream of the native ...