Positron emission particle tracking (PEPT) has been used to investigate the motion of radioactively labeled tracer particles attached fabrics and solid fabric enhancer (SFE) delivery articles, such as dryer sheets, in domestic clothes dryer. This work examines dynamics within across a range operating conditions. Six regions drum are identified, demonstrating movements experienced by items durin...

The objective was to study the effects of weaning in week 5 (W5) vs. 4 (W4), as well liquid (LF) dry feed (DF), on growth performance, disaccharidase activity and nutrient transporter expression after weaning. experiment included 12,923 pigs fed LF or DF pre-weaning period a subpopulation 15 from each group, W4DF, W4LF, W5DF W5LF, which were weighed euthanized five days proximal part small inte...

Among drug-induced renal failure, direct renal tubular toxicity, typically described as toxic acute tubular necrosis, is often associated with increased cellular uptake of nephrotoxic compounds. Drug transporters in tubular cells are the first fundamental stage in the development of the nephrotoxic process. Several examples can be given of organic substances that are nephrotoxic only after bein...

Peptide transporters of the SLC15 family are classified by structure and function into PEPT1 (low-affinity/high-capacity) and PEPT2 (high-affinity/low-capacity) isoforms. Despite the differences in kinetics, both transporter isoforms are reckoned to transport essentially all possible di- and tripeptides. We here report that the fluorophore-conjugated dipeptide derivatives β-Ala-Lys-N-7-amino-4-...

Major facilitator superfamily (MFS) peptide transporters (typically referred to as PepT, POT or PTR transporters) mediate the uptake of di- and tripeptides, and so play an important dietary role in many organisms. In recent years, a better understanding of the molecular basis for this process has emerged, which is in large part due to a steep increase in structural information. Yet, the conform...

29 Roche, P. C., Ryan, R. J. and McCormick, D. J. (1992) Endocrinology (Baltimore) 131,268-274 Atassi, M. Z., Manshouri, T. and Sakata, S. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 3613-3617 Dattatreyamurty, B. and Reichert, L. E., Jr. (1992) Mol. Cell. Endocrinol. 87, 917 Acher, R. (1993) Regul. Pept. 45, 1-13 Yamano, Y., Ohyama, K., Chaki, S., Guo, D.-F. and Inagami, T. (1992) Riochem. Biophys...

9 Hart, G. R., Gowing, H. and Burrin, J. M. (1992) J. Endocrinol. 134, 33-41 10 Koch, B. and Lutz-Bucher, B. (1992) Regul. Pept. 38, 45-53 11 Propato-Mussafiri, R., Kanse, S. M., Ghatei, M. A. and Bloom, S. R. (1992) J. Endocrinol. 132, 107-1 13 12 Watanabe, T., Masuo, Y., Matsumoto, H., Suzuki, N., Ohtaki, T., Masuda, Y., Kitada, C., Tsuda, M. and Fujino, M. (1992) Biochem. Biophys. Res. Commu...

The purpose of this study was to evaluate the role, relevance, and regional dependence of peptide transporter (PEPT) 1 expression and function in mouse intestines using the model dipeptide glycylsarcosine (GlySar). After isolating specific intestinal segments, in situ single-pass perfusions were performed in wild-type and Pept1 knockout mice. The permeability of [(3)H]GlySar was measured as a f...