: Pepsin is an aspartate protease that generated from its proenzyme, pepsinogen by autocatalysis initiated a fall in pH below 5. Human gastric juice contains eight isoenzymes of pepsin. The peptides released on conversion to pepsin which there are potentially five, have been shown antimicrobial activity against wide range bacteria including Escherichia coli, Pseudomonas and Staphylococcus also ...

1. Pepsinogen B, the precursor of pepsin B, has been isolated by ion-exchange chromatography and gel filtration from neutral extracts of pig gastric mucosa. The material possesses potential activity against acetyl-l-phenylalanyl-l-di-iodotyrosine and against gelatin but has little, if any, potential activity against haemoglobin. 2. The material appears homogeneous in the ultracentrifuge, but on...

Phenylbutazone in moderate dosage has been administered to 15 patients with a variety of musculo-skeletal disorders. A rise in plasma pepsinogen activity occurred in 13, generally reaching a peak in the first week of treatment; subsequently there was a fall in spite of maintaining a constant dosage. In four of six patients an anticholinergic drug failed to prevent a rise in plasma pepsinogen ac...

Objective: This study aims to investigate the clinical significance of gastrin 17 and pepsinogen in gastric cancer and precancerous lesion screening. Methods: We used ELISA to measure the levels of gastrin 17 and pepsinogen in serum from the medical examination population, which compared to endoscopic results. Then statistical analysis was performed. Results: The classical method by testing pep...

Pepsinogen has been purified from the fundic mucosa of the dog. The preparation is homogeneous by chromatography, amino terminal analysis, ultracentrifugation, electrophoresis on cellulose acetate strips, and disc electrophoresis. Analysis indicates the presence of 352 amino acid residues, at least 12 moles of carbohydrate including some amino sugars, and 1 mole of organic phosphate per mole of...

reacted with other reactive groups in the protein. However, it would appear that, whatever other reactions may have occurred, the increase in specifically monitors the extent of modification of histidine residues only. Thus diethyl pyrocarbonate appears to have reacted with pig pepsinogen to modify, at least, all three histidine residues in the protein. Once again, therefore, the potential acti...

The aim of this study was to determine the age-specific prevalence of Helicobacter pylori infection in infants and children aged 1-99 months from a poor periurban community in Bangladesh. We also examined the frequency of infection among infants and their 53 immediate family members and evaluated the relationship between infection and fasting serum group II pepsinogen (pepsinogen II) concentrat...

Bovine pepsinogen is converted into pepsin by removal of 45 amino acid residues from the NH, terminus of the single polypeptide chain. The complete sequence of the activation peptides has been deduced from two overlapping sets of peptides, one set obtained by autoactivation of the zymogen at pH 2 and the second set from a tryptic digest of maleylated pepsinogen. A peptide derived from the 17 re...