Civet, the perineal gland secretion of Malabar Civet cat (Moschothera civettina blyth) in doses ranging from 100 to 800 mg/kg p.o. produced significant potentiation of pentobarbitone induced hypnosis, mild analgesis and anticonvulsant activities. However, it is devoid of hypothermic effect in mice and antipyretic activity in febrile rats. It also failed to produce any effect in the "rota - rod ...

A comparison was made in seven dogs anaesthetized with pentobarbitone of cardiovascular measurements during ventilation with 65-70% nitrous oxide in oxygen and ventilation with 65-70% nitrogen in oxygen. The substitution of nitrous oxide for nitrogen was found to be associated, after 15 min, with a significant decrease in cardiac output and significant increases in right atrial and left ventric...

Material and Methods. The animals were given increasing concentrations (10% ethanol (v/v) in water for 1week, 20% (v/v) for another 2 weeks and 30% (v/v) for 9 weeks) per os daily. Treatment with the extract (250 and 500 mg/kg) was instituted 6 h after given the alcohol for the same period the alcohol intake lasted. Thereafter, the activities of alanine aminotransferase (ALT), aspartate amino t...

OBJECTIVE The present study was undertaken to evaluate anti-depressant activity of Myristica fragrans (MS). MATERIALS AND METHODS Male Wistar rats were subjected to imipramine and herbal extract of MS for their antidepressant activity using Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST). RESULTS Administ...

Mentha arvensis Linn, a plant used as traditional medicine and in perfumery, has now been explored for its pharmacological activities as an anti-inflammatory and also as sedativehypnotic plant drug. The methanolic extract of the leaves after being processed, was taken for the pharmacological study. Anti-inflammatory activity was carried out on albino rats. Further, the activity was compared to ...