It is demonstrated theoretically that the absorptivity of bulk shear sagittal waves by an ultra-thin layer of viscous fluid between two different elastic media has a strong maximum (in some cases as good as 100%) at an optimal layer thickness. This thickness is usually much smaller than the penetration depths and lengths of transverse and longitudinal waves in the fluid. The angular dependencie...

Limited distribution of anticancer drugs has been recognized as a significant hurdle to efficacy. We investigated a detailed penetration/distribution profile of paclitaxel-rhodamine (PTX-rd) and doxorubicin (DOX) in multicellular layer (MCL) cultures of human cancer cells as an in vitro model for avascular regions of solid tumors. MCLs were exposed to drugs and fluorescent images of frozen sect...

Recently efficient model-checking tools have been developed to find flaws in security protocols specifications. These flaws can be interpreted as potential attacks scenarios but the feasability of these scenarios need to be confirmed at the implementation level. However, bridging the gap between an abstract attack scenario derived from a specification and a penetration test on real implementati...

In order to form a nanostructured metallic layer below a Langmuir monolayer, radiolysis synthesis was carried out in an adapted geometry that we call surface X-ray radiolysis. In this procedure, an X-ray beam produced by a synchrotron beamline intercepts the surface of an aqueous metal-ion solution covered by a Langmuir monolayer at an angle of incidence below the critical angle for total inter...

The »Formulating for Efficacy« concept is a systematic approach to simultaneously optimize the driving force of the active ingredient (so that it partitions in larger quantities into the stratum corneum) and reduce its concentration in the formulation without a loss of clinical efficacy. Its ultimate aim is to optimize the clinical efficacy via enhancement of the skin delivery of the active pri...

We consider the swelling kinetics of layered structures. We focus on the case of triblock copolymer mesogels, although our results are applicable to other layered structures including clays. We assume the mesogels are swollen by a solvent that is good for the bridging block but poor for the non-bridging block. At long times the penetration front moves as in ordinary diffusion, i.e., as t1/2. At...

The move to the cloud brings a number of new security challenges, but the application remains your last line of defense. Engineers are extremely well poised to perform tasks critical for securing the application—provided that certain key obstacles are overcome. Cloud Shifts the Burden of Security to Development

Penetration testing entails attacking a system to identify and report insecurity, but doing so without harming the system nor encroaching on the dignity of those affected by it. To improve the interaction between penetration testers and their processes and technology, we need to understand the factors that affect decisions they make with ethical import. This paper presents four ethical hazards ...