Background Autoimmune bullous diseases (AIBD) are rare disorders characterized by autoantibody formation against components of adhesion molecules; in pemphigoid (PD), these proteins hemidesmosomes and basement membrane, important for cell-matrix skin and/or mucous membranes. Incidences vary considerably between different populations. Objectives To establish a registry prospectively recruiting a...

Animal models of human diseases are very useful to better understand their pathomechanism and to develop new therapies. However, due to the differences among different species, it is sometimes difficult to reproduce reliable diseases phenotype in animals. Bullous pemphigoid is the most common autoimmune blistering skin disease, in which circulating IgG autoantibodies directed against type XVII ...

BP: bullous pemphigoid BPAG: bullous pemphigoid antigen CVA: cerebrovascular accident INTRODUCTION Bullous pemphigoid (BP) is an autoimmune disease that results in the formation of tense bullae, usually affecting the elderly population. The pathogenesis involves deposition of IgG autoantibodies in basement membrane hemidesmosomes followed by complement activation and subsequent recruitment of i...

OBJECTIVES To describe a method to measure the progression of ocular cicatricial pemphigoid and to compare its facility with traditional methods used to measure the progression of the disease. METHODS The proposed method consists of measuring (in millimeters) the total relative inferior conjunctival surface available in 3 gaze positions. This method was used to monitor 7 eyes of 4 patients wi...

Pemphigus vulgaris is an autoimmune bullous dermatosis presenting with flaccid blisters and erosions. The morphology of pemphigus reflects the more superficial intraepidermal level split seen histologically in contrast pemphigoid, where deep below epidermis. This a case 58-year-old male clinically arcuate tense bullae, which are characteristic pemphigoid group disorders, revealed tombstoning pa...

BP: bullous pemphigoid PD-1: programmed cell-death receptor

Bullous pemphigoid is an autoimmune blistering skin disease characterized by the presence of circulating autoantibodies which recognize specific proteins of the epidermis and dermoepidermal junction. Diagnosis is based on clinical criteria and laboratory investigations, notably histology, direct and indirect immunofluorescence, and ELISA. This study describes a new immunofluorescence assay for ...

Bullous pemphigoid (BP) and psoriasis vulgaris represent two clinically well characterized, inflammatory, chronic skin diseases. A 62 years old female patient, from rural areas, was admitted for the presence of erythematous plaques covered by large tense blisters with clear fluid, located symmetrically on the anterior part of the upper limbs, the trunk, the neck and the lower limbs. Also the le...