BACKGROUND In the present study, we aimed to retrospectively analyze the correlation between toxicity of pemetrexed (PEM) chemotherapy and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms in patients with advanced non-squamous non-small cell lung cancer (non-sq NSCLC). MATERIAL AND METHODS We used polymerase chain reaction, gene scanning, and restriction fragment length polymorph...

Production efficiency models (PEMs) are based on the theory of light use efficiency (LUE) which states that a relatively constant relationship exists between photosynthetic carbon uptake and radiation receipt at the canopy level. Challenges remain however in the application of the PEM methodology to global net primary productivity (NPP) monitoring. The objectives of this review are as follows: ...

OBJECTIVE To assess growth hormone (GH)/insulin like growth factor-1 (IGF-1) axis as a possible non-nutritional factor for growth retardation in children with cerebral palsy (CP). METHODS A case-control study was conducted at a tertiary university hospital. Thirty children with CP (seven children with normal growth [CP-N] and 23 with retarded growth [CP-R]), 30 children with protein energy ma...

OBJECTIVE To determine the prevalence, risk factors, co-morbidities and case fatality rates of Protein Energy Malnutrition (PEM) admissions at the paediatric ward of the University of Nigeria Teaching Hospital Enugu, South-east Nigeria over a 10 year period. DESIGN A retrospective study using case Notes, admission and mortality registers retrieved from the Hospital's Medical Records Departmen...

F uel cells have tantalized engineers for more than a century as efficient devices to directly convert chemical energy to electrical energy. However, fuel cell use has been limited to niche applications, like space vehicles and emergency backup power systems, due to their expensive components and specialized fuel requirements. During the past two decades polymer electrolyte membrane (PEM) fuel ...

We propose a point-based environment model (PEM) to represent the absolute coordinate frame in which camera motion is to be tracked. The PEM can easily be acquired by laser scanning both indoors and outdoors even over long distances. The approach avoids any expensive modeling step and instead uses the raw point data for scene representation. Also the approach requires no additional artificial m...

Polyelectrolyte multilayer (PEM) films, established using the layer-by-layer (LbL) technique, are attractive for controlled drug delivery in order to improve tissue regeneration. For instance, the LbL-deposition provides the possibility to incorporate biomolecules via electrostatic interactions for drug delivery, which might be moreover combined with a stable biofunctionalization via covalent b...

Correlation analysis of mid-arm circumference (MAC), weight-for-age and weight-for-height obtained from 807 Malay preschool children aged 12-71 months show that MAC had a relatively low correlation with weight-for-age (r = 0.59, P < 0.001) and weight-for-height (r = 0.63, P< 0.001). MAC percentiles and sensitioity-specificity analysis indicate that when weight-for-age and weight-for-height were...

Ascidian embryogenesis is regarded as a typical ‘mosaic’ type. Recent studies have provided convincing evidence that components of the posterior-vegetal cytoplasm of fertilized eggs are responsible for establishment of the anteroposterior axis of the embryo. We report here isolation and characterization of a novel maternal gene, posterior end mark (pem). After fertilization, the pem transcript ...

Replication of time series in microarray experiments is costly. To analyze time series data with no replicate, many model-specific approaches have been proposed. However, they fail to identify the genes whose expression patterns do not fit the pre-defined models. Besides, modeling the temporal expression patterns is difficult when the dynamics of gene expression in the experiment is poorly unde...