Luotonins are alkaloids from the aerial parts of Peganum nigellastrum Bunge. that display three major skeleton types. Luotonins A, B, and E are pyrroloquinazolino-quinoline alkaloids, luotonins C and D are canthin-6-one alkaloids, and luotonin F is a 4(3H)-quinazolinone alkaloid. All six luotonins have shown promising cytotoxicities towards selected human cancer cell lines, especially against l...

ETHNOPHARMACOLOGICAL RELEVANCE Peganum harmala is used in traditional medicine to treat a number of diseases including cancer. Our preliminary studies show that the alkaloidal extract of PH seed is cytotoxic to several tumor cell lines in vitro and has antitumor effect in a tumor model in vivo. The present investigation was aimed at extending our previous studies in identifying the components i...

peganum harmala is a plant that is traditionally used as an analgesic, anti-inflammatory, antibacterial, antioxidant, anti-helmintic, and antimutagenic agent. moreover, it is used to treat a variety of human ailments, including depression. this study was conducted to investigate the antidiabetic activity of hydro alcoholic extract of this herb. a hydro alcoholic extract from seeds of this herb ...

background & aims of the study: heavy metals discharge to environment is a worldwide problem growing in scale. when they accumulate in the environment and in food chains, they can profoundly disrupt biological processes. peganum harmala seeds (phs) was used as a bio-sorbent, using a continuous system for removing pb2+, co2+, ni2+ and cu2+ ions from aqueous solutions. materials and methods: phs ...

the enzymatic potential of the cultured plant cells can be employed for bioconversion purposes. plant enzymes are able to catalyze regio- and stereo-specific reactions, and therefore can be applied for the production of desired substances. the biotransformation of foreign substrates with suspension cells of peganum harmala was tested with (±) phenylethyl propionate. the callus cultures of pegan...

This study compared the genetic diversity within and among six naturally growing coastal and inland populations of Peganum harmala by using random amplified polymorphic DNA (RAPD) technique. Seven primers generated a total of 63 RAPD bands (loci) of which 60 (95.24%) were polymorphic across all individuals. The genetic diversity of P. harmala at the population level and species level were perce...

BACKGROUND In vitro and in vivo antileishmanial activities of crude hydroalcoholic extract of peganum harmala seeds were investigated against Leishmania major. METHODS The extract of aerial parts of P harmala was obtained by maceration. The in vitro experiments were performed on promastigotes to assess antileishmanial activity of the extract using amphotericin B as a reference. The in vivo st...

The active parts of 11 medicinal plants were analyzed for physico-chemical evaluation, phytochemical determination and antioxidant activity. The physico-chemical evaluation revealed that highest water soluble extractive was from Origanum vulgare (38%), highest chloroform extractive was from Psoralea corylifolia (21%); highest ethanolic extractive was that of Acorus calamus (11%) and the highest...