BACKGROUND The relative contribution and the relation between individual peanut allergens in peanut allergic responses is still matter of debate. We determined the individual contribution of peanut proteins to B, T cell and allergic effector responses in a mouse model for peanut allergy. METHODS Mice were immunized and challenged by oral gavage with peanut protein extract or isolated allergen...

BACKGROUND AND OBJECTIVES Children with atopic dermatitis (AD) have a higher risk for development of food allergies. The objective of this study was to examine incidence of food allergy development in infants with AD and the predictive value of food-antigen-specific immunoglobulin E measurements. METHODS This trial examined the long-term safety and efficacy of pimecrolimus cream 1% in >1000 i...

Background Siblings of children with peanut allergy (PNA) are reported to have a higher prevalence of PNA than the general population. This prevalence may have both genetic and environmental influences, but may also reflect incorrect PNA diagnoses with less rigorous usage of confirmatory tests in siblings. The Peanut Allergy Registry (PAR), a Canadian database of individuals with PNA, was used ...

Results Mice treated with 2 mg peanut developed peanut-specific IgE levels which were significantly higher than control mice (p<0.001, n=10/group). Mice treated with 2 mg turkey developed a similar IgE response to turkey (p<0.001, n=10/group). In the second study, allergy was only triggered in one of ten mice treated with 2 mg peanut. Two of ten mice exposed to 1 mg potato had a response. There...

BACKGROUND Component-based diagnosis on multiplex platforms is widely used in food allergy but its clinical performance has not been evaluated in nut allergy. OBJECTIVE To assess the diagnostic performance of a commercial protein microarray in the determination of specific IgE (sIgE) in peanut, hazelnut, and walnut allergy. METHODS sIgE was measured in 36 peanut-allergic, 36 hazelnut-allerg...

BackgroundIndividuals with 1 legume allergy may be cosensitized to other legumes and thus potentially have allergies as well. Although the use of emerging (eg, pea, lentils, chickpeas) in commercial food production is increasingly common, literature has largely focused on peanut soy, both which are priority allergens Canada.ObjectiveWe aimed describe distribution Canada, consideration for patie...

Can the burden of disease due to food allergy be prevented? " What is food to one, to another is rank poison " —Titus Lucretius Cato (98 –55 BC) F rom time immemorial, there have been early descriptions of harmful reactions seen after the in-gestion of food that substantiate our continued interest and study of food allergy (FA) today. At no time has the potential for prevention and management o...

BACKGROUND We previously estimated that the annual rate of accidental exposure to peanut in 1411 children with peanut allergy, followed for 2227 patient-years, was 11.9% (95% CI, 10.6, 13.5). This cohort has increased to 1941 children, contributing 4589 patient-years, and we determined the annual incidence of accidental exposure, described the severity, management, location, and identified asso...

BACKGROUND Recent reports indicate that dendritic cell (DC)-derived T-cell immunoglobulin and mucin domain molecule (TIM)-4 plays an important role in the initiation of T(H)2 polarization. This study aims to elucidate the mechanisms of peanut allergy mediated by microbial products and DCs and the relationship between peanut allergy and TIM4. METHODS Mouse bone marrow-derived DCs (BMDCs) were ...

Methods Peanut allergic adults (n=94) and children (n=100) with a suspected peanut allergy were included. sIgE levels were measured by ImmunoCAP (Uppsala, Sweden). In all subjects the adapted Mueller score was used with one additional category for no symptoms (0-5): 0; no symptoms/peanut tolerant, 1; oral allergy symptoms, 2; cutaneous/mucosal symptoms, 3; gastrointestinal symptoms, 4; respirat...