In this study, we tested the hypothesis that chronic administration of phencyclidine (PCP), an N-methyl-D-aspartate (NMDA) receptor antagonist, would cause a long-lasting behavioral sensitization associated with neuronal toxicity. Female Sprague-Dawley rats were administered PCP (20 mg/kg, i.p.) once a day for 5 days, withdrawn for 72 hr, placed in locomotor activity chambers, and challenged wi...

R.E. SOLOMON, S. HERLING and J.H. WOODS, Discriminative stimulus effects of monohydroxylated phencyclidine metabolites in rhesus monkeys, European J. Pharmacol. 82 (1982) 233-237. Rhesus monkeys were trained to discriminate saline from an injection of ketamine. In tests of stimulus generalization, phencyclidine (PCP) produced dose-related ketamine-appropriate responding in each monkey. Two mono...

OBJECTIVE To examine the preventive effects of prophylaxis against Pneumocystis jiroveci-induced pneumonia (PCP) in patients receiving immunosuppressive therapy for rheumatoid arthritis (RA) who are colonized by this organism. METHODS We performed molecular testing by polymerase chain reaction (PCR) for P. jiroveci on induced sputum or bronchoalveolar lavage fluids of 82 patients with RA. Dur...

In order to model exposure to ingredients contained in personal care products (PCPs) and assess their potential risks to human health, access to reliable PCP use data, including co-use patterns, is essential. A postal questionnaire survey was conducted to determine the use patterns of eight leave-on PCP categories among the German-speaking population of Switzerland (N = 1,196; ages 0-97 years),...

The existence of multiple receptor sites for the psychotomimetic agents phencyclidine (PCP) and some opiate-benzomorphans such as (+)N-allylnormetazocine ([+]SKF 10,047) in the mammalian central nervous system is well documented. These are: 1) sigma/PCP (sigma p) site, which binds both PCP and psychotomimetic opiates but not antipsychotics such as haloperidol, 2) PCP site, which selectively bin...

Pentachlorophenol (PCP) was more rapidly degraded in acetate and glucose-fed microbial fuel cells (MFCs) than in open circuit controls, with removal rates of 0.12 ± 0.01 mg/Lh (14.8 ± 1.0 mg/g-VSS-h) in acetate-fed, and 0.08 ± 0.01 mg/L h (6.9 ± 0.8 mg/g-VSS-h) in glucose-fed MFCs, at an initial PCP concentration of 15 mg/L. A PCP of 15 mg/L had no effect on power generation from acetate but po...

Several potential mechanisms of surfactant-induced inhibition of pentachlorophenol (PCP) biodegra-dation were tested using a pure bacterial culture of Sphingomonas chlorophenolicum sp. Strain RA2. Concentrations of the surfactant Tergitol NP-10 (TNP10) over 200 mg/L inhibit biodegradation of PCP at concentrations below 100 mg/L. At PCP concentrations above 200 mg/L, TNP10 reduced the substrate ...

The combined anaerobic-aerobic conditions in air-cathode single-chamber MFCs were used to completely mineralize pentachlorophenol (PCP; 5 mg/L), in the presence of acetate or glucose. Degradation rates of 0.140 ± 0.011 mg/L-h (acetate) and 0.117 ± 0.009 mg/L-h (glucose) were obtained with maximum power densities of 7.7 ± 1.1 W/m(3) (264 ± 39 W/m(2), acetate) and 5.1 ± 0.1 W/m(3) (175 ± 5 W/m(2)...

Planar cell polarity (PCP) is critical for morphogenesis in metazoans. PCP in vertebrates regulates stereocilia alignment in neurosensory cells of the cochlea and closure of the neural tube through convergence and extension movements (CE). Noncanonical Wnt morphogens regulate PCP and CE in vertebrates, but the molecular mechanisms remain unclear. Smurfs are ubiquitin ligases that regulate signa...

The influence of pH on the sorption of pentachlorophenol (PCP) onto three organic amendments, char, humic acid (HA) and peat, and the effect of organic amendments on PCP sorption to three kinds of soils were evaluated. The sorption of PCP on these sorbents fitted the Freundlich model well, suggesting that PCP sorption isotherms were nonlinear with exponential coefficient (N) value lower than 1....