pH-responsive drug delivery systems could mediate drug releasing rate by changing the pH values at specific times as per the pathophysiological need of the disease. This paper demonstrates that a mussel-inspired protein polydopamine coating can tune the loading and releasing rate of charged molecules from electrospun poly(ε-caprolactone) (PCL) nanofibers in solutions with different pH values. I...

Number of Papers published in peer-reviewed journals: Final Report: Instrumentation for Investigating the Regenerative Potential of Bone-Tissue-Engineered Scaffolds Report Title This research aims to develop polymeric nanofibers that can be used as tissue scaffolds. Nanoscale fiber scaffolds provide an optimal template for cells to seed, migrate and grow. The goal is for the cells to attach to ...

Combined therapy with drugs of different therapeutic effects is an effective way in the treatment of diseases and damaged tissues or organs. However, how to precisely control the release order, dose, and time of the drugs using vehicles is still a challenging task. In this work, for the first time, a study to develop a nanoscale multi-drug delivery system based on polymer micelle-enriched elect...

Novel biodegradable multiblock copolymers of [PCL-b-P(THF-co-CL)]m with PCL fractions of 53.3 and 88.4 wt % were prepared by Janus polymerization of ε-caprolactone (CL) and tetrahydrofuran (THF). Their electrospun mats were obtained with optimized parameters containing bead-free nanofibers whose diameters were between 290 and 520 nm. The mechanical properties of the nanofiber scaffolds were mea...

The ability to produce composite nanofibers from synthetic and natural polymers represents a significant advancement in development of composite materials with structural and material properties that will support biomedical applications such as tissue engineering, drug delivery and wound healing. In this research composite nanofiber membranes of magnesium oxide (MgO), poly (ε-caprolactone) (PCL...

Hyphenated electrospinning electrospraying is a versatile method for synthesizing polymeric functional materials with fascinating and tuneable characteristics. In this paper, previously unreported clusters of boron nitride nanotubes (BNNTs) their hybrid nanofibers ɛ-polycaprolactone (PCL) were fabricated successfully. For instance, biocompatible nano fibrous mat may have potent to encapsulate c...

In this work, fluorescent gold nanocluster (AuNC) decorated polycaprolactone (PCL) nanofibers (AuNC*PCL-NF) for real time visual monitoring of Hg(2+) detection at ppt level in water is demonstrated. The resultant AuNC*PCL-NF exhibiting remarkable stability more than four months at ambient environment and facilitates increased accessibility to active sites resulting in improved sensing performan...

Biomaterial properties and controlled architecture of scaffolds are essential features to provide an adequate biological and mechanical support for tissue regeneration, mimicking the ingrowth tissues. In this study, a bioextrusion system was used to produce 3D biodegradable scaffolds with controlled architecture, comprising three types of constructs: (i) poly(ε-caprolactone) (PCL) matrix as ref...

INTRODUCTION The native inability of nervous system to regenerate, encourage researchers to consider neural tissue engineering as a potential treatment for spinal cord injuries. Considering the suitable characteristics of induced pluripotent stem cells (iPSCs) for tissue regeneration applications, in this study we investigated the adhesion, viability and proliferation of neural progenitors (der...

A tubular poly(ε-caprolactone) (PCL)/poly(lactide-co-glycolide) (PLGA) ureteral stent composed of nanofibers with micropores was fabricated by double-needle electrospinning. The stent was ureteroscopically inserted into six Changbai pigs, and the commercial polyurethane Shagong(®) stent was inserted into four pigs as control. Intravenous pyelography revealed that the PCL/PLGA stent gradually de...