نتایج جستجو برای: pbp2a
تعداد نتایج: 180 فیلتر نتایج به سال:
Community-type Staphylococcus aureus strains that are positive for mecA and PBP2a but appear phenotypically susceptible to oxacillin are increasingly reported worldwide. Four S. aureus clinical isolates carrying the mecA gene with oxacillin MICs of <2 microg/ml were tested for oxacillin efficiency by population analyses and experimental thigh infections. These isolates harbored staphylococcal c...
The aim of this study was to evaluate methicillin resistance detection methods currently used when studying coagulase-negative staphylococci (CONS). The resistance to oxacillin of 142 strains from seven species of CoNS isolated from the Intensive Care Unit environments was tested. The methods used were: disc diffusion test with cefoxitin (FOX30) and oxacillin (OX1), oxacillin agar screen test w...
β-Lactam antibiotics have long been a treatment of choice for bacterial infections since they bind irreversibly to Penicillin-Binding Proteins (PBPs), enzymes that are vital for cell wall biosynthesis. Many pathogens express drug-insensitive PBPs rendering β-lactams ineffective, revealing a need for new types of PBP inhibitors active against resistant strains. We have identified alkyl boronic a...
The species of the genus Tabernaemontana have a long tradition use in different pathologies infectious origins; antibacterial, antifungal, and antiviral effects related to control where this are used, been attributed indole monoterpene alkaloids, mainly those iboga type. There more than 1000 alkaloids isolated from other genera Apocynaceae family, several which lack studies antibacterial activi...
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