STUDY OBJECTIVES
Evaluate the hypnotic efficacy of gaboxadol, a selective extrasynaptic GABAA agonist (SEGA), in a phase advance model of transient insomnia.
DESIGN
A randomized, double-blind, cross-over study in which habitual sleep time was advanced by 4 h.
SETTING
Sleep research laboratories.
PARTICIPANTS
109 healthy subjects (18-58 y).
INTERVENTIONS
Gaboxadol 5 mg, 10 mg, and 15 mg ...