The genome of human T-cell leukemia virus (HTLV) was surveyed in fresh tumor cells of 163 patients with lymphoma and leukemia from the southwest part of Japan where adult T-cell leukemia (ATL) is endemic. Leukemic cells of all 88 cases of ATL tested so far were found to contain the provirus genome and also found to be monoclonal with respect to the integration site of provirus genome. In most c...

The association between non-Hodgkin lymphoma, including chronic lymphocytic leukemia, and aggressive skin cancers is well established. This review highlights existing data that address increased incidence and clinical characteristics of skin cancers in patients with non-Hodgkin lymphoma-specifically, chronic lymphocytic leukemia. Patients with non-Hodgkin lymphoma have worse outcomes when melan...

BACKGROUND Abnormal NK phenotype and cytotoxic functions have been described in acute myeloid leukemia, chronic lymphocytic leukemia, myeloma and myelodysplastic syndromes. Defective NK cytotoxicity is due to decreased expression of the Natural Cytotoxicity Receptors (NCRs), 2B4/CD244/p38, or NKG2D. This prompted us to test the expression of these molecules on circulating NK cells from patients...

Patients with diffuse large B cell lymphoma can occasionally develop hypercalcemia but it is rare at the onset of disease. We present a case of an elderly female who presented with refractory hypercalcemia, workup of which led to the diagnosis of B cell lymphoma. We discuss about various etiologies for development of hypercalcemia in a patient with lymphoma or leukemia.

Tumor lesion of the orbit is found in clinic various oncohematological diseases children. Untimely referral such patients to an oncologist delays timing necessary treatment, thereby worsening prognosis disease. The literature review presents features clinical manifestations orbital pathology children at onset acute myeloid leukemia, sarcoma, lymphoma, Langerhans cell and non-Langerhans histiocy...

introduction acute lymphoblastic leukemia (all) is the most common malignancy of childhood. patients with all commonly present with easy bruising and infections due to medullary involvement. the extra medullary involvements of all manifests as hepatosplenomegaly, lymphadenopathy, and testicular enlargement. among extramedullary manifestations of the all, thyroid involvement is rare. herein, we ...

The BRAF-V600E mutation defines genetically hairy cell leukemia among B-cell leukemias and lymphomas. In solid tumors, BRAF-V600E is known to aberrantly activate the oncogenic MEK-ERK pathway, and targeted BRAF and/or MEK inhibitors have shown remarkable efficacy in clinical trials in melanoma patients. However, the MEK-ERK pathway status in hairy cell leukemia has not been thoroughly investiga...

We have studied the antileukemic effects of cyclosporin-A (CyA) on the cells of a number of human hematopoietic biopsies and established cell lines in vitro. Cya killed the tumor cells but not the nonmalignant control cells from three of four patients with T-lymphocytic leukemia/lymphoma at concentrations comparable to those recommended in clinical long-term immunosuppressive therapy. The leuke...

Background & Objective: Although the antigen expression patterns of acute lymphoblastic leukemia (ALL) are well known, this study attempted to evaluate commonly used immune markers for immunophenotyping of acute leukemia to set the minimum of necessary diagnostic panels by flow cytometry. Methods: This study evaluated 89 patients referred from all over th...